NCT06711016: MNM-ECPR

Multimodal Neurological Monitoring Strategy After Receiving ECPR

Not yet recruiting NA Last updated 2 December 2024

What this trial tests

NA trial testing fluid resuscitation, vasoactive drug dose,hemoglobin transfusion,sedative analgesic muscle relaxant drugs, antiepileptic drugs, etc in Cardiac Arrest in 654 participants. Not yet recruiting.

Timeline

1 December 2024

Primary endpoint
30 May 2028

30 July 2028

Quick facts

Lead sponsor	Qilu Hospital of Shandong University
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	single
Primary purpose	treatment
Enrollment	654
Start date	1 December 2024
Primary completion	30 May 2028
Estimated completion	30 July 2028
Sites	1 location across China

Drugs / interventions tested

• fluid resuscitation, vasoactive drug dose,hemoglobin transfusion,sedative analgesic muscle relaxant drugs, antiepileptic drugs, etc

Conditions studied

• Cardiac Arrest — all drugs for Cardiac Arrest →

Sponsor

Qilu Hospital of Shandong University

Who can join

Adults 18 to 75, any sex, with Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Neurological injury remains an important cause of morbidity and mortality in patients with ECPR. At present, the results of three prospective randomized controlled studies on ECPR are inconsistent, and it is inconclusive whether ECPR can improve the neurological outcomes of patients with refractory cardiac arrest. Several study found that extracorporeal membrane oxygenation nonsurvivors can lead toacute brain injury.Further research with a systematic neurologic monitoring is necessary to define the timing of acute brain injury in patients with extracorporeal membrane oxygenation.Moreover, brain injury that occurs during extracorporeal membrane oxygenation therapy is not easy to detect in time because of the use of analgesics, sedatives, and muscle relaxants. Surprisingly, little attention has been paid to the role of cerebral perfusion and oxygenation. Moreover,the features of cerebrovascular pathophysiology and optimal management strategies are still vague.

Therefore multimodal neuromonitoring may be a valuable tool for detecting brain injury in patients with extracorporeal membrane oxygenation and providing early intervention guidance.

The aim of this study is to test whether multimodal neuromonitoring will improve 30-day survival with a favorable neurologic outcome in ECPR patients with a refractory OHCA.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Noninvasive multimodal neuromonitoring in patients with post-cardiac arrest brain injury: a survey from China's intensive care units.
   Ren Y, Nie X, Liu H, Jiang T, et al · · 2025 · PMID 39920785 · DOI 10.1186/s13054-025-05293-y