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NCT06705101
Gabapentin and Pressor Response to Intubation
Phase 1, PHASE2 trial testing Gabapentin Group (Group G): Patients will receive 300 mg of oral Gabapentin in Elective Surgical Patients in 144 participants. Not yet recruiting.
15 June 2025
Quick facts
| Lead sponsor | Liaquat National Hospital & Medical College |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 144 |
| Start date | 15 December 2024 |
| Primary completion | 15 June 2025 |
| Estimated completion | 16 July 2025 |
Drugs / interventions tested
- Gabapentin Group (Group G): Patients will receive 300 mg of oral Gabapentin — full drug profile →
- Placebo Oral Tablet — full drug profile →
Conditions studied
- Elective Surgical Patients — all drugs for Elective Surgical Patients →
- Blood Pressure — all drugs for Blood Pressure →
Sponsor
Liaquat National Hospital & Medical College
Who can join
Adults 18 to 59, any sex, with Elective Surgical Patients or Blood Pressure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates the effectiveness of oral gabapentin in reducing the pressor response (increased MAP, HR, and BP) during laryngoscopic intubation. It is a prospective, double-blind randomized controlled trial involving 144 patients undergoing elective surgery. Gabapentin 300 mg or placebo will be administered preoperatively, with hemodynamic parameters monitored before and after intubation. The study aims to determine if gabapentin attenuates the sympathetic stress response compared to placebo.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06705101
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06705101 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Liaquat National Hospital & Medical College
- Last refreshed: 26 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06705101.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing