Last reviewed · How we verify
NCT06705010: SIGNATURES2023
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
NA trial testing Application of new pulse sequence package SIGNATURES2023 to healthy controls in Aging in 140 participants. Not yet recruiting.
1 November 2026
Quick facts
| Lead sponsor | Insel Gruppe AG, University Hospital Bern |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 140 |
| Start date | 1 April 2025 |
| Primary completion | 1 November 2026 |
| Estimated completion | 31 March 2028 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Application of new pulse sequence package SIGNATURES2023 to healthy controls
- Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
Conditions studied
- Aging — all drugs for Aging →
- Brain Metabolic Disorder — all drugs for Brain Metabolic Disorder →
- Carotid Stenosis — all drugs for Carotid Stenosis →
- Alzheimer Disease — all drugs for Alzheimer Disease →
Sponsor
Insel Gruppe AG, University Hospital Bern
Who can join
Adults 18 to 130, any sex, with Aging or Brain Metabolic Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla. The study has 4 phases. Phase I: The 2H and 1H MRSI sequences are developed and optimized in vitro (phantoms) Phase II: Sequences are applied in vivo in healthy volunteers and further optimized Phase III: Optimal 2H 1H pulse sequences are applied in 4 cohorts of healthy volunteers, to study the effect of aging with whole brain 2H and 1H MRSI. Phase IV: application of the sequences in 4 patient groups with different diseases: Alzheimer's diseases (AD) patients, diabetes mellitus type II (DM) patients, mild cognitive impaired (MCI) patients, and high grade carotid stenosis patients (HGCS). The ultimate aim is to create for individual patient specific 3dimensional spatial resolved z-score maps (similar to FDG-PET) based on the healthy control data of phase III of the trial.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06705010
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Insel Gruppe AG, University Hospital Bern trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06705010 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Insel Gruppe AG, University Hospital Bern
- Last refreshed: 25 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06705010.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing