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NCT06704425
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults
trial testing For observational studies, participants are not assigned an intervention as part of the study. in Chronic Non-Specific Low Back Pain in 80 participants. Currently enrolling.
30 April 2025
Quick facts
| Lead sponsor | The Hong Kong Polytechnic University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 20 April 2024 |
| Primary completion | 30 April 2025 |
| Estimated completion | 1 November 2025 |
| Sites | 3 locations across Hong Kong |
Drugs / interventions tested
- For observational studies, participants are not assigned an intervention as part of the study.
Conditions studied
- Chronic Non-Specific Low Back Pain — all drugs for Chronic Non-Specific Low Back Pain →
- Cognitive Decline — all drugs for Cognitive Decline →
- Cross-Sectional Study — all drugs for Cross-Sectional Study →
- Older Adults — all drugs for Older Adults →
Sponsor
The Hong Kong Polytechnic University
Who can join
Adults 60 to 85, any sex, with Chronic Non-Specific Low Back Pain or Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic non-specific low back pain (CNSLBP) is a prevalent condition among older adult and has been associated with an increased risk of executive function impairment. Studies have shown that older adults with chronic pain are more likely to show poor cognitive performance than healthy controls. Cognitive performance is particularly important when managing pain in older adults, especially for some executive functions (e.g., inhibition, switching, working memory) because pain and executive functions have their bidirectional relationship. Further, executive dysfunctions are associated with a decline in functional status among older adults, particularly the impairment of instrumental activities of daily living. Given the above, the preservation of executive functions emerges as a pivotal consideration among old adults with CNSLBP. Studies have provided preliminary evidence of the correlation between brain changes associated with chronic pain and cognitive functions. For example, multisite chronic pain may contribute to an increased risk of cognitive decline via structural change in hippocampal atrophy. For another example, functional brain changes in chronic pain reduced the deactivation of several key default mode network regions, thereby predisposing individuals to cognitive impairments. Despite the aforementioned brain changes, no research has provided direct evidence to support the hypothesis that structural and functional brain changes caused by CNSLBP in older adults may be associated with cognitive decline. Specifically, whether CNSLBP may lead to structural changes (e.g., smaller hippocampal, cerebellar gray matter, white matter volume in the right frontal region) and/or functional changes (e.g., deactivation of default mode network regions, heightened activation in the anterior cingulate cortex) associated with cognitive decline remains unclear. With the help of neuroimaging, the knowledge about the underlying brain mechanisms between CNSLBP (chronic non-specific low back pain) and executive functions can be explained. To gain a better understanding of the brain mechanisms underlying executive function decline in older adults with CNSLBP, this study will directly compare pain intensity, executive functions, brain structure, and functional changes of the brain between older adults with CNSLBP and age-matched healthy controls. The results of this study have the potential to quantify the association between CNSLBP-related brain changes and executive functions in older adults, and provide insights into the development of new treatment strategies to improve or prevent executive function decline in older adults with CNSLBP.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06704425
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06704425 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hong Kong Polytechnic University
- Last refreshed: 26 November 2024
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