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NCT06698159: WIDER-PVI
Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)
NA trial testing Cryoablation with cryoballoon 28 mm in Atrial Fibrillation in 440 participants. Currently enrolling.
1 May 2026
Quick facts
| Lead sponsor | Hospital Universitario 12 de Octubre |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 440 |
| Start date | 1 November 2024 |
| Primary completion | 1 May 2026 |
| Estimated completion | 30 June 2027 |
| Sites | 17 locations across Italy, Spain |
Drugs / interventions tested
- Cryoablation with cryoballoon 28 mm
- Cryoablation with cryoballoon 31 mm
Conditions studied
- Atrial Fibrillation — all drugs for Atrial Fibrillation →
- Atrial Fibrillation (Paroxysmal) — all drugs for Atrial Fibrillation (Paroxysmal) →
Sponsor
Hospital Universitario 12 de Octubre
Who can join
18 and older, any sex, with Atrial Fibrillation or Atrial Fibrillation (Paroxysmal). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The WIDER PVI study is a multicentre randomized clinical trial to compare the efficacy of antral versus extended antral PVI in patients with paroxysmal or persistent AF undergoing this procedure using a cryoablation balloon capable of 28 mm diameter (antral isolation) or 31 mm diameter (extended antral isolation) applications. The aim is to evaluate an objective of superiority of the extended antral isolation strategy versus antral isolation in the recurrence of atrial tachyarrhythmias at 1-year follow-up, both in episodes of \>30 seconds duration and in overall arrhythmic load.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Wide-Antral pulmonary vein isolation in patients undergoing atrial fibrillation ablation with a Single-Shot technique: rationale and design of the WIDER-PVI trial.
Cobarro L, Negreira-Caamaño M, Gómez-Burgueño L, López-Alacid I, et al · · 2026 · PMID 41196540 · DOI 10.1007/s10840-025-02173-x
Verify or expand the search:
- PubMed search for NCT06698159
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Atrial Fibrillation
Currently open trials in the same condition.
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Other Hospital Universitario 12 de Octubre trials
Trials by the same sponsor.
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- NCT07095829 — Prognostic Model of Postnatal Circulation in Pulmonary Atresia-critical Stenosis With Intact Ventricular Septum · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06698159 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hospital Universitario 12 de Octubre
- Last refreshed: 20 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06698159.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing