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NCT06697145
Assessment of the Durability of Cardioneuroablation Using Physiological Indices of Heart Rate Reactivity
NA trial testing Cardioneuroablation in Syncope, Vasovagal, Neurally-Mediated in 12 participants. Completed in 31 December 2024.
31 December 2024
Quick facts
| Lead sponsor | Wroclaw Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 12 |
| Start date | 23 November 2021 |
| Primary completion | 31 December 2024 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Cardioneuroablation
Conditions studied
- Syncope, Vasovagal, Neurally-Mediated — all drugs for Syncope, Vasovagal, Neurally-Mediated →
Sponsor
Wroclaw Medical University
Who can join
Adults 18 to 80, any sex, with Syncope, Vasovagal, Neurally-Mediated. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cardioneuroablation is a novel treatment option for reflex-mediated syncope. It involves thermal destruction of neural tissue in the close proximity of heart using catheter introduced to the heart through vein in the groin. Effectiveness of the procedure is satisfactory, however, in some cases there is a possibility of the re-growth of previously ablated tissue. We aim to investigate whether this process could be traced by measurement of various physiological parameters related to heart rate reactivity. Additionally we intend to reveal whether changes in those parameters over time could influence clinical effeciveness of the procedure.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cardioneuroablation Acutely Affects the Amplitude and Efficiency of Respiratory Heart Rate Variability.
Niewinski P, Tubek S, Nowak K, Josiak K, et al · · 2026 · PMID 41517631 · DOI 10.3390/jcm15010382
Verify or expand the search:
- PubMed search for NCT06697145
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
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- medRxiv preprints
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Related trials
Other trials of Cardioneuroablation
Trials testing the same drug.
- NCT07468383 — Basic and Clinical Study of Cardiac Ganglion Catheter Ablation for the Treatment of Significant Bradycardia · NA · recruiting
- NCT06159764 — National Registry of Cardioneuroablation in Recurrent Reflex Syncope · recruiting
- NCT05896592 — Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted Pacemaker · NA · recruiting
- NCT06472102 — Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography · NA · recruiting
- NCT06458140 — Cardioneuroablation and Ventricular Proarrhythmia · NA · recruiting
Other recruiting trials for Syncope, Vasovagal, Neurally-Mediated
Currently open trials in the same condition.
- NCT06513650 — Mechanism-based Therapy of Hypotensive Syncope · recruiting
Other Wroclaw Medical University trials
Trials by the same sponsor.
- NCT07413419 — Evaluation of Remote Motivational Interviewing for Disease Management in Heart Failure Patients and Their Carers · NA · not yet recruiting
- NCT07159932 — Poland Integrated Medicines Management (PL-IMM) - Study Assessing the Provision of Complex Clinical Pharmacy Services to · NA · not yet recruiting
- NCT07141745 — Electroporation vs. Radiofrequency Ablation Guided by 3D Imaging in Repeat Procedures for Atrial Fibrillation · NA · recruiting
- NCT07099885 — Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure · NA · recruiting
- NCT07157475 — Vascular Complications in Patients Undergoing Peripheral Revascularization and Taking SGLT-2 Inhibitors · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06697145 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wroclaw Medical University
- Last refreshed: 30 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06697145.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing