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NCT06696781
NOL Index in Response to Pacemaker Stimulation
trial testing Pacemaker stimulation in Nociceptive Pain in 20 participants. Completed in 1 July 2025.
1 June 2025
Quick facts
| Lead sponsor | Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 18 November 2024 |
| Primary completion | 1 June 2025 |
| Estimated completion | 1 July 2025 |
| Sites | 1 location across Romania |
Drugs / interventions tested
- Pacemaker stimulation
Conditions studied
- Nociceptive Pain — all drugs for Nociceptive Pain →
Sponsor
Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Who can join
Adults 18 to 80, any sex, with Nociceptive Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The Nociception Level Index (NOL Index) utilizes various signals to assess the balance of nociception and antinociception during anesthesia. Its correlation with nociceptive stimuli and opioids is known, but its response to isolated heart rate changes remains uncertain. The aim is to investigate how cardiac pacing affects the NOL Index.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Nociception level index response to pacemaker stimulation.
Balan C, Barbulescu RT, Dumitrache A, Fodoroiu A, et al · · 2025 · PMID 41182599 · DOI 10.1007/s10877-025-01377-w
Verify or expand the search:
- PubMed search for NCT06696781
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu trials
Trials by the same sponsor.
- NCT06814561 — Hemodynamic Determinants of Urine Output During Spinal Anesthesia · completed
- NCT06499701 — Volume Kinetics of Fluid Resuscitation in Early Sepsis · recruiting
- NCT06474052 — Volume Kinetics of Gelofusine 4% During Vascular Surgery · completed
- NCT06070701 — NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block · NA · completed
- NCT06440772 — Portal Vein Pulsatility Index to Assess Fluid Intolerance · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06696781 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
- Last refreshed: 11 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06696781.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing