NCT06692751: EYE-NOCA

The Value of Measuring Retinal Vascular Density by Optical Coherence Tomography-Angiography (OCT-A) in Patients With Microvascular Angina Confirmed by Myocardial Microcirculatory Resistance Index (MRI).

Recruiting now Last updated 12 February 2026

What this trial tests

trial testing Blood sampling in Microvascular Angina in 158 participants. Currently enrolling.

Timeline

13 November 2024

Primary endpoint
1 November 2027

1 November 2027

Quick facts

Lead sponsor	Centre Hospitalier Universitaire Dijon
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	158
Start date	13 November 2024
Primary completion	1 November 2027
Estimated completion	1 November 2027
Sites	1 location across France

Drugs / interventions tested

• Blood sampling — full drug profile →
• Ophthalmological examination
• angina severity questionnaire

Conditions studied

• Microvascular Angina — all drugs for Microvascular Angina →

Sponsor

Centre Hospitalier Universitaire Dijon

Who can join

18 and older, any sex, with Microvascular Angina. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Retinal vascular density by "inner vessel length density" determined by OCT-A
  Time frame: At baseline

Sponsor's own description

Microvascular angina is thought to affect around 112 million patients worldwide. However, this figure is underestimated due to the difficulty of making the diagnosis. It is a pathology caused by an alteration in the microcirculation of the heart muscle, which is not detectable on a standard coronary angiogram.

In view of its prognostic, therapeutic and medico-economic value, scientific societies currently recommend invasive measurement of the microcirculatory resistance index (MRI) to diagnose microvascular angina, in the absence of significant lesions on coronary angiography.

Several research teams, including our own, have shown that cardiovascular risk is associated with alterations in the vascularization of the small vessels (microcirculation) of the retina. Unlike the study of cardiac vessels, the study of retinal microcirculation using fundus photography (OCT-A) is simple, rapid, non-invasive and inexpensive. It appears to be an interesting alternative to the measurement of IMR for the diagnosis of microvascular angina.

This hypothesis has never yet been tested. The demonstration of an association between a decrease in retinal vascular density measured by OCT-A and an alteration in coronary microvascular function measured by IMR would pave the way for a completely non-invasive diagnosis of patients.

This is an observational, cohort, prospective, single-center pilot study comparing people who have received an IMR measurement as part of INOCA.

It is planned to include 158 participants. The overall follow-up period for each patient in the research is 12 months.

In routine care, IMR is measured during coronary angiography in patients presenting with ischemia on a non-invasive test and/or stress symptoms such as angina or dyspnea, for whom coronary angiography does not reveal any significant epicardial lesion.

Following this examination, two groups will be formed: a group with an IMR\<25 and a group with an IMR≥25. Clinically, the study aims to determine the potential role of retinal OCT-A as a non-invasive examination for the diagnosis and/or follow-up of INOCA.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.