NCT06690749: Negative press

Using Skin Blood Flow to Measure the Effect of Different Doses of Negative Pressure Therapy

Completed NA Last updated 15 November 2024

What this trial tests

NA trial testing Negative pressure therapy, NPT in Hypertrophic Scars in 36 participants. Completed in 11 May 2023.

Timeline

11 May 2022

Primary endpoint
11 May 2023

11 May 2023

Quick facts

Lead sponsor	Asia University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	36
Start date	11 May 2022
Primary completion	11 May 2023
Estimated completion	11 May 2023
Sites	1 location across Taiwan

Drugs / interventions tested

• Negative pressure therapy, NPT

Conditions studied

• Hypertrophic Scars — all drugs for Hypertrophic Scars →

Sponsor

Asia University

Who can join

18 and older, any sex, with Hypertrophic Scars. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Introduction. Skin blood flow (SBF) is crucial for transporting nutrients during healing to treat scarring. Negative pressure therapy (NPT) is a promising option to enhance SBF. However, it is unclear what dosage of NPT is most effective in treating scars.

This study compared NPT dosages of -105 mmHg, -125 mmHg, and -145 mmHg to assess the impact of NPT treatment on SBF in scar tissue and the correlation of NPT. If participants experience any symptoms of discomfort, NPT can be discontinued immediately.

36 scarred subjects were recruited to assess the efficacy of various NPT interventions. SBF applications are defined as perfusion levels instantly affecting NPT, and termination is defined as SBF after NPT.

The study runs from May 11, 2022, to May 11, 2023, at Asia University Hospital.

This study was funded by the National Science and Technology Council, Taiwan (NSTC 112-2221-E-468-004)

The main contact was Chi-Wen Lung, the person in charge of a college or university department of Product Design, Asia University, Taichung 413305, Taiwan.Email address: [e-mail]

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effect of Negative Pressure Therapy on Skin Blood Flow Responses in Scar Tissue.
   Shen WC, Cheng HT, Jan YK, Liau BY, et al · · 2025 · cited 1× · PMID 40979006 · DOI 10.7759/cureus.90436