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NCT06683599: SEALION
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
NA trial testing Apneic oxygenation in Difficult Airway in 240 participants. Currently enrolling.
1 June 2026
Quick facts
| Lead sponsor | Vinícius C Quintão, MD, MSc, PhD |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 240 |
| Start date | 10 December 2024 |
| Primary completion | 1 June 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 3 locations across Sweden, Australia, Brazil |
Drugs / interventions tested
- Apneic oxygenation
Conditions studied
- Difficult Airway — all drugs for Difficult Airway →
- Difficult Airway Intubation — all drugs for Difficult Airway Intubation →
- Neonate — all drugs for Neonate →
Sponsor
Vinícius C Quintão, MD, MSc, PhD
Who can join
Adults 1 Minute to 52 Weeks, any sex, with Difficult Airway or Difficult Airway Intubation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Tracheal intubation in neonates can be technically challenging, even for experienced pediatric anesthesiologists, with a high first-attempt success rate crucial to ensure safety. Intubation, while life-saving for children with circulatory shock or respiratory failure, carries risks of severe desaturation that can lead to hypoxic encephalopathy, cardiac arrest, or death. Neonates, especially, are prone to hypoxemia due to high oxygen consumption, low functional residual capacity, small closing capacity, and increased risk of airway collapse, which is exacerbated under anesthesia and neuromuscular paralysis. Rapid desaturation occurs after cessation of ventilation, with neonates facing shorter apnea times before desaturation. Studies show that about two-thirds of neonates undergoing non-emergency nasotracheal intubation experience desaturation (SpO₂ \<80% for over 60 seconds), although low-flow oxygen supplementation (0.2 L/kg/min) can extend safe apnea time. This study aims to investigate apneic oxygenation with VL (using Miller or Macintosh blades size 0 or 1) in operating rooms or intensive care units. We hypothesize that supplemental oxygen and standardized VL use will improve first-pass success rates and reduce adverse events.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06683599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Apneic oxygenation
Trials testing the same drug.
- NCT07189338 — Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation · NA · not yet recruiting
- NCT04885673 — High Flow Nasal Cannula in Comparison to Apneic Oxygenation During Foreign Body Removal by Rigid Bronchoscope · NA · unknown
Other recruiting trials for Difficult Airway
Currently open trials in the same condition.
- NCT07470736 — Comparative Study Between Combined Video Laryngoscope and Video Stylet Intubation Versus Combined Video Laryngoscope and · NA · recruiting
- NCT07384494 — High-flow Nasal Cannula Versus Conventional Oxygen During Awake Tracheal Intubation With Difficult Airways · NA · recruiting
- NCT06986187 — Difficult Airway Incidence in Cardiovascular Surgery and a Prediction Model Development · recruiting
- NCT06884592 — Determination of the Frequency and Predictors of Difficult Intubation in Septoplasty Operations · recruiting
- NCT06836388 — Using Ultrasound for Bougie Insertion in Difficult Airway Management · NA · active not recruiting
Other Vinícius C Quintão, MD, MSc, PhD trials
Trials by the same sponsor.
- NCT06683586 — Brazilian Registry of Chronic Venous Disease - Risk Factors, Comorbidities, Clinical and Surgical Treatment · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06683599 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vinícius C Quintão, MD, MSc, PhD
- Last refreshed: 25 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06683599.
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