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NCT06681025

Clinical Performance Evaluation of the NeuMoDx™ EBV Quant Assay 2.0 in Immunocompromised Transplant Patients

Completed Last updated 8 November 2024
What this trial tests

trial testing NeuMoDx EBV Quant 2.0 Assay in EBV Viremia in 1,070 participants. Completed in 15 March 2024.

Timeline
31 August 2022
Primary endpoint
31 December 2023
15 March 2024

Quick facts

Lead sponsorQIAGEN Gaithersburg, Inc
StatusCompleted
Study typeOBSERVATIONAL
Enrollment1,070
Start date31 August 2022
Primary completion31 December 2023
Estimated completion15 March 2024
Sites1 location across United Kingdom

Drugs / interventions tested

Conditions studied

Sponsor

QIAGEN Gaithersburg, Inc — full company profile →

Who can join

18 and older, any sex, with EBV Viremia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The NeuMoDx EBV Quant Assay 2.0 study is a multi-center, observational clinical investigation designed to evaluate the performance of the NeuMoDx EBV Quant Assay 2.0 in quantifying Epstein-Barr virus (EBV) DNA levels in plasma samples from immunocompromised transplant patients. The study compares the NeuMoDx EBV assay's performance against an FDA-cleared comparator assay under routine clinical use conditions, utilizing both the NeuMoDx™ 96 and NeuMoDx™ 288 Molecular Systems. The aim is to demonstrate the quantitative concordance and clinical utility of the assay in monitoring EBV DNA levels as part of patient management.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Performance evaluation of the NeuMoDx™ EBV Quant Assay 2.0 in Comparison with cobas® EBV for epstein-barr virus DNA quantification in immunocompromised patients, a multicenter study.
    Doseeva V, Mostafa HH, Rhoads D, Relich RF, et al · · 2025 · PMID 40578123 · DOI 10.1016/j.diagmicrobio.2025.116956

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