Who is sponsoring CRANE?

CRANE is sponsored by Vikas Kotagal.

What condition does CRANE study?

CRANE studies Parkinson Disease.

What drugs are being tested in CRANE?

Interventions: Placebo, Varenicline.

Last reviewed 2026-03-25 · How we verify

Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease (CRANE)

NCT06679374 Phase 2 RECRUITING

This trial aims to test whether one year of Varenicline, when compared to placebo, can reduce fall risk and show improvement in the ability to multitask while walking. Participants that are eligible after screening for the study will be randomized to receive Varenicline or placebo. Along with the study medication participants will have visits (over the phone and in person), various tests and imaging, questionnaires, and laboratory collections.

Details

Lead sponsor	Vikas Kotagal
Phase	Phase 2
Status	RECRUITING
Enrolment	102
Start date	2025-04-09
Completion	2029-01

Conditions

Parkinson Disease

Interventions

Placebo
Varenicline

Primary outcomes

Change in normal pace-dual task cost (npDTC) from baseline to 12 months. — Baseline, 12 months
Normal pace-dual task cost is defined as the within-subject difference between normal pace walking speed without dual tasking to normal pace walking speed with dual tasking divided by normal pace walking speed without dual tasking, multiplied by 100.

Countries

United States