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NCT06674629: EELI and AHFNC
Asymmetrical High Flow Nasal Cannula and End-Expiratory Lung Impedance
trial testing High flow oxygen therapy in End-Expiratory Lung Impedance in 17 participants. Completed in 31 January 2025.
31 December 2024
Quick facts
| Lead sponsor | Argentinian Intensive Care Society |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 17 |
| Start date | 5 November 2024 |
| Primary completion | 31 December 2024 |
| Estimated completion | 31 January 2025 |
| Sites | 1 location across Argentina |
Drugs / interventions tested
- High flow oxygen therapy
Conditions studied
- End-Expiratory Lung Impedance — all drugs for End-Expiratory Lung Impedance →
- Respiratory Rate — all drugs for Respiratory Rate →
- Diaphragm Thickness Fraction — all drugs for Diaphragm Thickness Fraction →
- Diaphragm Excursion — all drugs for Diaphragm Excursion →
Sponsor
Argentinian Intensive Care Society
Who can join
Adults 18 to 50, any sex, with End-Expiratory Lung Impedance or Respiratory Rate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Objective: The primary aim is to assess end-expiratory lung impedance (EELI) changes during the application of high-flow oxygen therapy using asymmetric nasal cannulae, comparing conditions with the mouth closed and open in healthy volunteers in various positions. The secondary objective includes evaluating respiratory rate, shortening fraction, and diaphragm excursion via ultrasound. Study Design: This is a prospective observational cohort study conducted in the Critical Care Unit of Sanatorio Parque Rosario from November 5 to December 31, 2024. It will involve 20 healthy adult volunteers without respiratory conditions, with informed consent obtained from all participants. Volunteers with contraindications for electrical impedance tomography (EIT) will be excluded. Methods: Equipment Used: PulmoVista 500 Dräger (EIT), AIRVO 2 (high-flow oxygen generator), asymmetric nasal cannula (Optiflow OPT 966), Toshiba iStyle ultrasound machine. Procedures: The study includes EELI measurements in different positions (semi-seated, supine Fowler, prone, and prone Fowler) with various high-flow oxygen settings (40 and 60 L/min). Diaphragm excursion and thickening will be assessed using ultrasound. Scenarios and Measurements: 17 different testing scenarios will be conducted, with 16 intervals for washout breathing at room air between scenarios. Data on EELI, respiratory rate, and diaphragm measurements will be collected.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06674629
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High flow oxygen therapy
Trials testing the same drug.
- NCT03828578 — Comparison of AIRVO High Flow Oxygen Therapy With Standard Care for Prevention of PPCs After Major H&N Surgery · NA · completed
- NCT03133520 — Effectiveness of High Flow Oxygen Therapy in Patients With Hematologic Malignancy Acute Hypoxemic Respiratory Failure · NA · completed
Other Argentinian Intensive Care Society trials
Trials by the same sponsor.
- NCT07017205 — Microaspiration and Endotracheal Tubes · NA · not yet recruiting
- NCT06837402 — Epidemiology of Non- Invasive Mechanical Ventilation in Argentina: a Multicenter Observational Study · enrolling by invitation
- NCT06824220 — Effect of High-Flow Tracheal Oxygen on EELI · NA · active not recruiting
- NCT06662201 — Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicente · active not recruiting
- NCT06536972 — Dual-focus Survey with an Emphasis on Heated Humidification Systems · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06674629 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Argentinian Intensive Care Society
- Last refreshed: 2 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06674629.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing