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NCT06674226
Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery
Phase 4 trial testing Ciprofol in Postoperative Delirium (POD) in 214 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Wang Tianlong |
|---|---|
| Phase | Phase 4 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 214 |
| Start date | 23 December 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 9 locations across China |
Drugs / interventions tested
Conditions studied
- Postoperative Delirium (POD) — all drugs for Postoperative Delirium (POD) →
Sponsor
Wang Tianlong
Who can join
65 and older, any sex, with Postoperative Delirium (POD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are many factors that make elderly patients prone to POD. On the basis of these factors, surgery and anesthesia can increase the incidence of POD in elderly patients. Deep depth of intraoperative anesthesia and persistent hypotension may increase the risk of POD occurrence in elderly patients. So far, no specific POD prevention method has been found. In recent years, a large number of studies on POD have brought forward more new views on its pathogenesis, prevention and treatment. There is insufficient evidence to recommend specific anesthetic agents and dosages to reduce the risk of POD in elderly patients, and only low-quality evidence to recommend propofol. At present, it is considered that the best way to reduce postoperative delirium is perioperative risk management, to evaluate high-risk patients or patients undergoing high-risk surgery as extensive as possible, and to quantify their risk of postoperative delirium. Effective measures include depth management of anesthesia, multi-modal analgesia management, and optimization of drug intervention. Ciprofol is a class 1 innovative drug independently developed by China and with global independent intellectual property rights. Ciprofol has been widely used in anesthesiology and critical care medicine. The pre-market phase I-III and post-market data showed that during the induction and maintenance of general anesthesia, Ciprofol had less impact on hemodynamics and more stable anesthesia depth than propofol. Relevant studies have shown that Ciprofol can reduce the risk of hypotension, and can provide better brain oxygenation and more stable intraoperative hemodynamics than propofol. At present, the influence of different sedative drugs on POD incidence in elderly patients remains to be studied. Therefore, we will apply Ciprofol or propofol in elderly patients undergoing thoracic surgery to observe their influence on POD incidence and provide reference for clinical use.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of ciprofol on postoperative delirium and outcomes in older patients undergoing major thoracic surgery: protocol for a multicentre, prospective, single-blinded, randomised controlled study.
Hong P, Liu Q, Ouyang W, Luo A, et al · · 2025 · cited 1× · PMID 40829819 · DOI 10.1136/bmjopen-2025-105818
Verify or expand the search:
- PubMed search for NCT06674226
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Ciprofol
Trials testing the same drug.
- NCT07376577 — Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP · NA · not yet recruiting
- NCT07294989 — The Effective Blood Concentration of Ciprofol · recruiting
- NCT06934811 — Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients · Phase 4 · not yet recruiting
- NCT06735430 — Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery · NA · completed
- NCT06531915 — Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy · NA · not yet recruiting
Other recruiting trials for Postoperative Delirium (POD)
Currently open trials in the same condition.
- NCT06788743 — Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surg · NA · recruiting
- NCT07324694 — Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery · recruiting
- NCT06901479 — The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery · active not recruiting
- NCT06687291 — Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer · recruiting
- NCT06818409 — Is the CRP-Albumin-Lymphocyte (CALLY) Index Effective in Predicting Postoperative Delirium in Geriatric Patients Undergo · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06674226 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wang Tianlong
- Last refreshed: 17 November 2025
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