NCT06670924

Suturing Techniques for Vesico-urethral Anastomosis

Completed NA Last updated 4 November 2024

What this trial tests

NA trial testing Running suture for vesico-urethral anastomosis in open radical prostatectomy in Prostate Cancer Surgery in 70 participants. Completed in 16 August 2024.

Timeline

7 February 2022

Primary endpoint
1 August 2023

16 August 2024

Quick facts

Lead sponsor	Kartal City Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	70
Start date	7 February 2022
Primary completion	1 August 2023
Estimated completion	16 August 2024
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Running suture for vesico-urethral anastomosis in open radical prostatectomy
• interrupted suture for vesico-urethral anastomosis in open radical prostatectomy

Conditions studied

• Prostate Cancer Surgery — all drugs for Prostate Cancer Surgery →

Sponsor

Kartal City Hospital

Who can join

Eligibility, male only, with Prostate Cancer Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Radical prostatectomy (RP) is the most common curative treatment for prostate cancer (PCa).Vesicourethral anastomosis (VUA) is a crucial step and either a conventional interrupted (IS) or a running (RS) suture is employed during radical prostatectomy (RP). Certainly, both RS and IS have advantages and limitations. The metanalysis revealed that potential advantages for RS compared to IS, especially for short-term outcomes such as catheterization time, extravasation rate, and anastomotic suture time. There were no significant differences for long-term outcomes (continence, incidence of vesicourethral anastomotic stenosis). Generally, the exciting evidence suggests that CS should be preferred over IS. However, this should be followed only if it is technically feasible and appropriate regarding the surgical approach. Both techniques seem to be safe and appropriate for the VUA, and the technique should be chosen based on individual experience and preference.

The investigators hypothesized that RS and IS may have different effects on voiding function and flow rate, even if they do not cause an anastomotic stenosis requiring intervention. Furthermore, there is no existing literature that compares RS and IS in terms of voiding function.This article focuses on one year uroflowmetric voiding parameters, urinary function (UF), and UF related bother function, urinary continence recovery as well as other secondary outcomes, including surgical parameters, perioperative morbidity and oncological outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. A Pragmatic Randomized Trial Comparing Suturing Techniques for Vesicourethral Anastomosis: One-Year Voiding Function Outcomes After Radical Prostatectomy.
   Can U, Dinçer E, Coşkun A, Mert MS, et al · · 2025 · PMID 40507695 · DOI 10.3390/jcm14113934