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NCT06670209
A Phase I Clinical Study to Evaluate the Effect of GZR18 Injection on the Pharmacokinetics of Oral Metformin Hydrochloride Tablets in Overweight/Obese Subjects
Phase 1 trial testing GZR18 and metformin in Type 2 Diabetes in 32 participants. Not yet recruiting.
19 March 2025
Quick facts
| Lead sponsor | Gan and Lee Pharmaceuticals, USA |
|---|---|
| Phase | Phase 1 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 32 |
| Start date | 30 October 2024 |
| Primary completion | 19 March 2025 |
| Estimated completion | 19 March 2025 |
Drugs / interventions tested
- GZR18 and metformin — full drug profile →
Conditions studied
- Type 2 Diabetes — all drugs for Type 2 Diabetes →
Sponsor
Gan and Lee Pharmaceuticals, USA — full company profile →
Who can join
Adults 18 to 50, any sex, with Type 2 Diabetes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a single-center, open-label, fixed-sequence phase I clinical study to evaluate the effect of multiple subcutaneous injections of GZR18 Injection on the pharmacokinetics of multiple oral doses of metformin hydrochloride tablets.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06670209
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Gan and Lee Pharmaceuticals, USA trials
Trials by the same sponsor.
- NCT07242664 — Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady State · Phase 1 · recruiting
- NCT07146347 — Comparison Study of Insulin GZR4 With Insulin Degludec · Phase 1 · recruiting
- NCT06737042 — Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants · Phase 2 · not yet recruiting
- NCT06547502 — Pharmacokinetics and Safety Profile of a Single Dose GZR4 in Subjects with Renal Impairment · Phase 1 · completed
- NCT06548906 — A Study of GZR4 Injection at Different Injection Sites · Phase 1 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06670209 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Gan and Lee Pharmaceuticals, USA
- Last refreshed: 1 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06670209.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing