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NCT06669026
The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic
Phase 2 trial testing vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel in Periodontal Pocket in 50 participants. Completed in 20 September 2024.
15 March 2024
Quick facts
| Lead sponsor | Mansoura University |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 September 2023 |
| Primary completion | 15 March 2024 |
| Estimated completion | 20 September 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel
- vitamin D3 gel (regular non-nanoparticle form)
- Poly lactic-co-glycolic acid nanoparticles placebo gel
- only mechanical debridement
Conditions studied
- Periodontal Pocket — all drugs for Periodontal Pocket →
Sponsor
Mansoura University
Who can join
Adults 25 to 55, any sex, with Periodontal Pocket. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06669026
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Mansoura University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06669026 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mansoura University
- Last refreshed: 1 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06669026.
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