Who is sponsoring NCT06668714?

NCT06668714 is sponsored by University of Aarhus.

What condition does NCT06668714 study?

NCT06668714 studies Pre Diabetes, Metabolic Syndrome.

What drugs are being tested in NCT06668714?

Interventions: Placebo + mixed meal, Lactate + mixed meal, PET-scan, Mixed meal with 18F-FTHA.

What is the status of NCT06668714?

NCT06668714 is currently RECRUITING.

Last reviewed 2025-06-16 · How we verify

Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?

NCT06668714 NA RECRUITING

Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes. Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.

Details

Lead sponsor	University of Aarhus
Phase	NA
Status	RECRUITING
Enrolment	25
Start date	2024-08-22
Completion	2026-01

Conditions

Pre Diabetes
Metabolic Syndrome

Interventions

Placebo + mixed meal
Lactate + mixed meal
PET-scan
Mixed meal with 18F-FTHA

Primary outcomes

Difference in meal fat uptake in heart tissue between CTR and LAC following a liquid test meal — 5-6 hours
The investigators will use a dynamic whole-body PET scan to determine dietary fatty acid trapping and distribution by measuring available 18F-FTHA-tracer in blood coupled with measurement of radioactivity in different organs. The investigators will also use the 18F-FTHA standardized uptake value (SUV) to evaluate dietary fatty acid trapping and distribution, to be able to compare our results with former studies using the 18F-FTHA method.

Countries

Denmark