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NCT06667336
The Impact of Suctioning on Oxygenation During RSI in the Emergency Department
NA trial testing intermittent suction in RSI in 76 participants. Completed in 28 October 2024.
31 May 2024
Quick facts
| Lead sponsor | Maimonides Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 76 |
| Start date | 1 September 2021 |
| Primary completion | 31 May 2024 |
| Estimated completion | 28 October 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- intermittent suction
- continuous suction
Conditions studied
- RSI — all drugs for RSI →
Sponsor
Maimonides Medical Center
Who can join
Adults 18 to 120, any sex, with RSI. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Rapid Sequence Intubation (RSI) is a common procedure in Emergency Departments (ED). However, it is a high-risk procedure and has been associated with significant complications including hypoxia, hypotension, airway trauma, aspiration, and death. Specifically, hypoxic episodes during intubation can lead to poor outcomes such as dysrhythmias, haemodynamic compromise, hypoxic brain injury and cardiac arrest, and is therefore of primary concern during any intubation procedure. Aspiration is a serious adverse event and potential cause of hypoxia during RSI and can lead to poor patient outcomes downstream of the procedure. The reported incidence of aspiration during RSI in the ED ranges from 3 to 8% in the ED population. In order to achieve an optimal view of the glottis and prevent pulmonary aspiration of fluids in the oropharynx, providers apply suction prior to and during laryngoscopy, using a Yankauer or large-bore suction catheter. There is currently significant variation in suctioning during laryngoscopy, with some providers using very little suction as needed to clear heavy fluids (judicious suctioning), while others utilise suction aggressively (lead with suction) and as a part of their routine laryngoscopy technique. Evidence suggests inline suction on already-intubated patients accelerates desaturation, but we are aware of no studies examining the impact suctioning has on the speed of desaturation during emergent endotracheal intubation. This pilot study aims to compare the effects of intermittent, as-needed "judicious" suctioning versus aggressive "continuous" (lead with) suctioning on oxygenation during rapid sequence intubation in the emergency department.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06667336
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other recruiting trials for RSI
Currently open trials in the same condition.
- NCT05775029 — RSI Observation Follow-up · active not recruiting
Other Maimonides Medical Center trials
Trials by the same sponsor.
- NCT07513493 — Pipelle vs the Curved Aspirator Device · Phase 4 · recruiting
- NCT07221175 — Operator Radiation Dose Using Ultra-Low Fluoroscopic Pulse Rate Versus Standard In Performing Coronary Angiography Via R · NA · withdrawn
- NCT06107725 — Maimonides Minocycline in Stroke Study · Phase 2, PHASE3 · terminated
- NCT06085586 — Fibulink Syndesmosis Repair System With Early Full-Weight Bearing · NA · recruiting
- NCT05615948 — Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression · Phase 4 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06667336 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maimonides Medical Center
- Last refreshed: 13 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06667336.
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