Last reviewed · How we verify
NCT06666660: CEDIRA
Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals
NA trial testing Multivitamin/Mineral supplements in Relatively Healthy Volunteers in 400 participants. Currently enrolling.
30 April 2025
Quick facts
| Lead sponsor | National University of Singapore |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | health services research |
| Enrollment | 400 |
| Start date | 23 September 2024 |
| Primary completion | 30 April 2025 |
| Estimated completion | 30 June 2025 |
| Sites | 2 locations across Singapore |
Drugs / interventions tested
- Multivitamin/Mineral supplements — full drug profile →
- Placebo
Conditions studied
- Relatively Healthy Volunteers — all drugs for Relatively Healthy Volunteers →
Sponsor
National University of Singapore
Who can join
Adults 40 to 60, any sex, with Relatively Healthy Volunteers. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Micronutrients, such as vitamins and minerals, are required to sustain fundamental physiological processes in individuals. As individuals age, the risk of having suboptimal levels of micronutrients increases due to several age-related changes affecting their digestion and assimilation processes. Suboptimal levels of micronutrients have been associated with increased risk of chronic diseases and accelerated ageing. Three years intake of a multivitamin and mineral supplement (MVM) improved global cognition, episodic memory and executive function in older adults. Furthermore, suboptimal micronutrient levels have been associated with a higher biological age, and diet and lifestyle interventions might lower the biological age measured by methylation clocks. Therefore, further evaluation is warranted to determine if MVM supplementation could improve the biological age and clinical outcomes in individuals with a higher biological age.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Perspective: Biomarkers of Aging in Human Nutrition Research-A Focus on Applications, Challenges, and Opportunities.
Loughlin KN, Grootswagers P, Camps G, de Groot LC. · · 2025 · cited 1× · PMID 40738225 · DOI 10.1016/j.advnut.2025.100486
Verify or expand the search:
- PubMed search for NCT06666660
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06666660 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National University of Singapore
- Last refreshed: 30 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06666660.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing