Does TXA Reduce Bruising After Hyaluronic Acid Filler Injection? A Prospective Half Face Study

NCT06665594 Phase 2 RECRUITING

The goal of this clinical trial is to look at the effect tranexamic acid (TXA) may have on reducing bruising, swelling, and pain after facial filler injection. The main question it aims to answer is: * Does the addition of TXA to hyaluronic acid (HA) reduce bruising, swelling, and tenderness after HA injection? Participants will receive the study medication along with the standard facial filler injection and complete surveys.

Details

Lead sponsor	University of Wisconsin, Madison
Phase	Phase 2
Status	RECRUITING
Enrolment	40
Start date	2025-12-05
Completion	2026-11

Conditions

• Facial Filler Injections
• Hyaluronic Acid
• Tranexamic Acid

Interventions

• Hyaluronic Acid (HA)
• Tranexamic Acid (TXA)
• Saline (placebo)

Primary outcomes

• Intensity of bruising on TXA + HA half of face — Post-procedure day 7
  Participants will score the intensity of bruising on a 5-point Likert scale, where 1 = no bruising and 5 = severe bruising.
• Intensity of bruising on saline + HA half of face — Post-procedure day 7
  Participants will score the intensity of bruising on a 5-point Likert scale, where 1 = no bruising and 5 = severe bruising.
• Duration of bruising on TXA + HA half of face — Post-procedure day 7
  Participants will indicate on what day their bruising disappeared, or whether it is still there.
• Duration of bruising on saline + HA half of face — Post-procedure day 7
  Participants will indicate on what day their bruising disappeared, or whether it is still there.

Countries

United States