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A Double-blinded, Randomized, Parallel-group, Superiority Study to Explore the Neuroprotective Effects of Long-term Transcutaneous Auricular Vagus Nerve Stimulation(taVNS) in Early Parkinson's Disease(PD) Patients (NLTVNSPD)
This study is a randomized, double-blind, controlled trial exploring the effects of long-term taVNS intervention in patients with early-stage Parkinson's disease.
Details
| Lead sponsor | Kezhong Zhang |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 12 |
| Start date | 2024-12-23 |
| Completion | 2026-06 |
Conditions
- Parkinson Disease, Idiopathic
Interventions
- taVNS real stimulation
- taVNS sham stimulation
Primary outcomes
- MDS-UPDRS-Ⅲ — baseline, 180±7 days, 360±7 days, 540±7 days，570±7 days
Used to evaluate the motor function. - Free water in the posterior substantia nigra (DTI) — baseline, 180±7 days, 360±7 days, 540±7 days，570±7 days
Used to measure progression of early Parkinson's disease.
Countries
China