NCT06655181

Evaluating the Effectiveness of Respiratory Muscle Training in Pediatric Kidney Transplant Patient

Completed NA Last updated 8 September 2025

What this trial tests

NA trial testing Respiratory Muscle Training in Chronic Kidney Disease(CKD) in 30 participants. Completed in 5 September 2025.

Timeline

27 May 2024

Primary endpoint
31 December 2024

5 September 2025

Quick facts

Lead sponsor	Atlas University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	30
Start date	27 May 2024
Primary completion	31 December 2024
Estimated completion	5 September 2025
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Respiratory Muscle Training

Conditions studied

• Chronic Kidney Disease(CKD) — all drugs for Chronic Kidney Disease(CKD) →
• Pediatric ALL — all drugs for Pediatric ALL →
• Pediatric Kidney Transplantation — all drugs for Pediatric Kidney Transplantation →
• Respiratory Muscle Training — all drugs for Respiratory Muscle Training →

Sponsor

Atlas University

Who can join

Adults 8 to 18, any sex, with Chronic Kidney Disease(CKD) or Pediatric ALL. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic kidney disease is defined as kidney damage lasting three months or longer and irreversible loss of renal function (glomerular, tubular and endocrine) or a glomerular filtration rate of less than 60 ml/min /1.73 m2 . Among the five stages of chronic kidney disease, the last and most severe stage is end-stage chronic kidney disease, which requires kidney transplantation. Many organs and systems are affected after kidney transplantation. Anemia, cardiovascular complications, secondary hyperparathyroidism, accumulation of uremic toxins, electrolyte disturbances, uremic myopathy, vitamin D deficiency, malnutrition, inflammation, atherosclerosis syndrome, and respiratory dysfunction and respiratory muscle weakness caused by oxidative stress leading to loss of muscle tissue are the most common changes seen in the pulmonary system. Children undergoing transplantation are at higher risk for cardiovascular diseases, usually associated with hypertension and dyslipidemia, which are already present in the chronic kidney disease stage and persist after transplantation. Significantly reduced muscle strength and physical activity in pediatric kidney transplant recipients is also frequently reported in the literature. Decreased exercise capacity, muscle strength and physical activity increase the risk of pulmonary and cardiovascular diseases. As chronic kidney disease progresses, pulmonary complications such as restrictive pulmonary dysfunction, respiratory muscle myopathy and decreased respiratory muscle strength are associated with disease severity. To improve respiratory muscle strength, respiratory muscle training is recommended for people with chronic kidney disease. The literature has so far demonstrated positive effects of inspiratory muscle training on respiratory muscle strength, diaphragm thickness and mobility, lung volumes, functional capacity and quality of life in many other patient populations, including lung and heart disease, cardiac surgery, thoracic surgery, multiple sclerosis and stroke. Although recent studies have found evidence of systemic changes after transplantation in both adults and children, there is little evidence of the efficacy of respiratory muscle training, especially in pediatric patients. In the light of all this information, the aim of our study was to investigate the efficacy of respiratory muscle training in children undergoing kidney transplantation.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.