NCT06653725 (KETO-AHF) is a Phase 2 clinical trial of 1,3-butanediol in Acute Heart Failure (AHF), sponsored by Aarhus University Hospital.

Who is sponsoring NCT06653725?

NCT06653725 is sponsored by Aarhus University Hospital.

What drugs are being tested in NCT06653725?

Interventions in NCT06653725: 1,3-butanediol, Placebo.

What condition does NCT06653725 study?

NCT06653725 studies Acute Heart Failure (AHF).

Is NCT06653725 still recruiting?

NCT06653725 is currently recruiting now. Last updated 5 June 2025.

Last reviewed 2025-06-05 · How we verify

NCT06653725: KETO-AHF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure

Recruiting now Phase 2 Last updated 5 June 2025

What this trial tests

Phase 2 trial testing 1,3-butanediol in Acute Heart Failure (AHF) in 250 participants. Currently enrolling.

Timeline

20 March 2025

Primary endpoint
1 November 2027

1 January 2028

Quick facts

Lead sponsor	Aarhus University Hospital
Phase	Phase 2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	250
Start date	20 March 2025
Primary completion	1 November 2027
Estimated completion	1 January 2028
Sites	8 locations across Denmark

Drugs / interventions tested

1,3-butanediol
Placebo

Conditions studied

Acute Heart Failure (AHF) — all drugs for Acute Heart Failure (AHF) →

Sponsor

Aarhus University Hospital

Who can join

18 and older, any sex, with Acute Heart Failure (AHF). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a multicenter, randomized, double-blind, placebo-controlled trial to investigate the clinical efficacy of treatment with exogenous dietary ketone supplement containing 1,3-butanediol in patients hospitalized with acute heart failure (AHF), potentially leading to better clinical outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Therapeutic Ketosis for Heart Failure: A State-of-the-Art Review.
Kodur N, Nguyen C, Tang WHW. · · 2025 · cited 5× · PMID 40043832 · DOI 10.1016/j.cardfail.2025.01.028

Verify or expand the search:

Other recruiting trials for Acute Heart Failure (AHF)

Currently open trials in the same condition.

NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
NCT07484009 — ReDS-guided Decongestion Strategy in Patients Hospitalized for Heart Failure · NA · recruiting
NCT07321509 — Digoxin After Acute Heart Failure · Phase 4 · recruiting
NCT07099885 — Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure · NA · recruiting

Other Aarhus University Hospital trials

Trials by the same sponsor.

NCT07432802 — Sublobar Wedge Resection or Stereotactic Radiotherapy Treatment of High-risk Patients With Early-stage Lung Cancer · NA · not yet recruiting
NCT07499336 — UNDERSTANDING THE T-CELL AND B-CELL RECEPTOR REPERTOIRE IN CHILDREN AND YOUNG ADULTS WITH ANTI-DRUG ANTIBODIES AGAINST P · not yet recruiting
NCT07454486 — TRACE-BTC. Relation of Biomarkers and Patients Reported Quality of Life to Outcomes in Patients With Biliary Tract Cance · not yet recruiting
NCT07284069 — Senicapoc and Perampanel for Newly Diagnosed Glioblastoma · EARLY_PHASE1 · recruiting
NCT07426250 — Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06653725 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aarhus University Hospital
Last refreshed: 5 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06653725.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing