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NCT06653699
Effectiveness of Peri-operative Combined Use of 2 Doses of Dexamethasone With Tranexamic Acid in Lower Limb Joint Replacements-A Randomized Controlled Trial.
NA trial testing 2 DOSES OF DEXAMETHASONE AND TRANEXAMIC ACID in Hip Replacement in 92 participants. Completed in 20 July 2025.
3 July 2025
Quick facts
| Lead sponsor | Indus Hospital and Health Network |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 92 |
| Start date | 11 July 2024 |
| Primary completion | 3 July 2025 |
| Estimated completion | 20 July 2025 |
| Sites | 1 location across Pakistan |
Drugs / interventions tested
- 2 DOSES OF DEXAMETHASONE AND TRANEXAMIC ACID — full drug profile →
- 1 DOSE OF DEXAMETHASONE AND TRANEXAMIC ACID — full drug profile →
Conditions studied
- Hip Replacement — all drugs for Hip Replacement →
- Knee Replacement — all drugs for Knee Replacement →
Sponsor
Indus Hospital and Health Network
Who can join
45 and older, any sex, with Hip Replacement or Knee Replacement. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this randomized controlled clinical trial is to investigate the effectiveness of peri operative use of 2 doses of dexamethasone with tranexamic acid in lower limb replacement, on post operative C-reactive protein (CRP), joint range of motion, fatigue, pain, hospital length of stay in male/female patients undergoing lower limb joint replacement, with pre op Hb above 10g/dL. The main question it aims to answer The peri operative use of 2 doses of dexamethasone with tranexamic acid in lower limb replacement, decrease the post operative CRP, fatigue, pain, hospital length of stay and increase the joint range of motion. Researcher will compare the two groups without knowing which group received either of 1 or 2 doses of Dexamethasone with TXA peri operatively. Patients will do answer the questions mentioned in questionnaire pre operatively, at post op 1st day, at 1st week and 4th week post discharge.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06653699
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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- Google Scholar
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Other Indus Hospital and Health Network trials
Trials by the same sponsor.
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- NCT06373900 — Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture. · NA · completed
- NCT07522619 — Comparison of Tubeless Versus Standard Percutaneous Nephrolithotomy (PCNL) for Renal Stones · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06653699 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indus Hospital and Health Network
- Last refreshed: 22 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06653699.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing