Last reviewed · How we verify
NCT06642480: Tramadol
Distribution of CYP2D6 Multiplication, CYP2D6*5, and Clinical Implications in Postoperative Patients Receiving Tramadol Analgesia in the Minangkabau Ethnic Group, Indonesia
NA trial testing Post Operative Analgesia in Post Operative Analgesia in 63 participants. Completed in 1 March 2023.
1 March 2023
Quick facts
| Lead sponsor | Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | none |
| Primary purpose | screening |
| Enrollment | 63 |
| Start date | 1 January 2022 |
| Primary completion | 1 March 2023 |
| Estimated completion | 1 March 2023 |
| Sites | 1 location across Indonesia |
Drugs / interventions tested
- Post Operative Analgesia — full drug profile →
- Post Operative Analgesia — full drug profile →
Conditions studied
- Post Operative Analgesia — all drugs for Post Operative Analgesia →
- Tramadol — all drugs for Tramadol →
Sponsor
Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia — full company profile →
Who can join
Under 65, any sex, with Post Operative Analgesia or Tramadol. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cytochrome P450 2D6 (CYP2D6) is an important enzyme in metabolizing commonly used drugs such as Tramadol hydrochloride (widely used opioid analgesic). Genetic polymorphisms of the CYP2D6 gene have been shown to influence the pharmacodynamic properties of the administered drug. This study aimed to screen 63 postoperative patients (wild-type, CYP2D6\*5, and CYP2D6 multiplication) of Minangkabau ethnicity in West Sumatera, Indonesia, who received tramadol using a modified long PCR method and to investigate the clinical impact of tramadol on the patients.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia.
Effendi R, Rizqia Haz A, Muhammad Fuad A, Dermawan B, et al · · 2024 · PMID 41078883 · DOI 10.12688/f1000research.155988.3 -
Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia
Effendi R, Rizqia Haz A, Muhammad Fuad A, Dermawan B, et al · · 2025 · DOI 10.12688/f1000research.155988.3 -
Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia
Effendi R, Rizqia Haz A, Muhammad Fuad A, Dermawan B, et al · · 2024 · DOI 10.12688/f1000research.155988.1
Verify or expand the search:
- PubMed search for NCT06642480
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Post Operative Analgesia
Trials testing the same drug.
- NCT06803966 — Comparison of Rescue Analgesia Requirement in Patients Undergoing Laparoscopic Cholecystectomy After Transversus Abdomin · Phase 2 · completed
Other recruiting trials for Post Operative Analgesia
Currently open trials in the same condition.
- NCT07508202 — Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Bloc · Phase 4 · recruiting
- NCT07388953 — Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimall · NA · recruiting
- NCT07242170 — Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Art · NA · recruiting
- NCT07088146 — Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients · Phase 4 · recruiting
- NCT07290595 — Comparative Analysis Of Dexmedetomidine And Dexamethasone As An Adjuvant To 0.5%Ropivacaine On Onset Of Ultrasound Guide · Phase 2, PHASE3 · recruiting
Other Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia trials
Trials by the same sponsor.
- NCT06688318 — Effectivity of Allogenic Umbilical Cord Mesenchymal Stem Cells Conditioned Media for Osteoarthritis of the Knee Joint · Phase 1, PHASE2 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06642480 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia
- Last refreshed: 24 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06642480.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing