Last reviewed · How we verify
The Effect of Nicotinamide on the Clinical Outcome of Rheumatoid Arthritis Patients (NAM&RA)
A randomized controlled interventional study to evaluate the efficacy and safety of nicotinamide supplementation in rheumatoid arthritis patients receiving conventional synthetic disease modifying anti-rheumatic drugs.
Details
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | Phase 2 |
| Status | RECRUITING |
| Enrolment | 70 |
| Start date | 2023-12-02 |
| Completion | 2025-06 |
Conditions
- Rheumatoid Arthritis
Interventions
- Nicotinamide Tablet
- conventional synthetic antirheumatic drugs
Primary outcomes
- Disease severity assessment using DAS-28 -CRP — At baseline and after three months.
DAS-28-CRP at baseline and at end of study, which will be calculated based on tender joint count (TJC) and swollen joint count (SJC) following the assessment of twenty-eight joints (figure 1) , serum CRP level, and the patient's global health assessment (PGA) on a scale from zero to one hundred. The score will be calculated using the following equation: (CASTREJÓN et al., 2010) DAS-28-CRP = 0.56\* √(TJC28) + 0.28\* √(SJC28) + 0.36\*ln (CRP + 1) +0.014\*(PGA) + 0.96
Countries
Egypt