NCT06639906

Is Preoperative Prediction of Intra-Abdominal Adhesions Possible?

Completed Last updated 6 April 2026

What this trial tests

trial in Adhesions Abdominal in 56 participants. Completed in 1 April 2026.

Timeline

14 January 2024

Primary endpoint
8 October 2024

1 April 2026

Quick facts

Lead sponsor	Celal Bayar University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	56
Start date	14 January 2024
Primary completion	8 October 2024
Estimated completion	1 April 2026
Sites	1 location across Turkey (Türkiye)

Conditions studied

• Adhesions Abdominal — all drugs for Adhesions Abdominal →
• Surgery — all drugs for Surgery →

Sponsor

Celal Bayar University

Who can join

Adults 18 to 50, female only, with Adhesions Abdominal or Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this study, it was aimed to evaluate the presence of intra-abdominal adhesion with biochemical markers before the operation, as well as to determine whether there is a relationship between the severity of adhesion and preoperative blood decorin and TGF β1 levels by examining intra-abdominal adhesions histopathologically.This study was conducted on patients who were hospitalized in the department of gynecology and obstetrics of our hospital between 01.09.2023 and 01.09.2024 (1 year) with laparotomy or laparoscopic abdominal surgery planned for gynecological reasons and who had at least 1 previous cesarean section or a history of previous abdominal surgery (laparoscopy or laparotomy). will be made among patients.

The study is voluntary and patients who meet the appropriate criteria will be informed verbally and written consent will be obtained from the patients. Preoperative blood samples will be taken from each patient included in the study. Patients with no adhesions detected in the abdomen during the operation will constitute the control group, and patients with adhesions detected will constitute the study group. The number of patients is planned to be 26 patients in the case group and 28 patients in the control group. Tissue samples removed from detected intra-abdominal adhesions will be taken for histological examination. The tissue samples obtained will be subjected to routine light microscopy tissue monitoring and embedded in paraffin blocks, 5 micron sections will be taken with a microtome and will be examined with a light microscope after being stained with Hematoxylin Eosin. Adhesions detected intra-abdominally are according to the "peritoneal adhesion index" classification; It will be graded in 4 stages: 0: No adhesion, 1: Thin adhesions, blunt dissection, 2: Dense adhesions, sharp dissection, 3: Dense dense and vascularized adhesions, sharp dissection, injury that can be prevented with difficulty. Thanks to the grading of intra-abdominal adhesions, it will be possible to evaluate not only whether the parameters examined are predictive of intra-abdominal adhesions, but also which degree of adhesions they are more effective in predicting. Whether the presence of intra-abdominal adhesion is predictable will be determined by comparing the decorin and TGF β biomarker levels in preoperative blood samples with the decorin and TGF β immunohistochemistry results in the adhesion tissue.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.