Last reviewed · How we verify
NCT06638918
Assessing the Feasibility of a Virtual Reality Intervention for Phantom Pain Immediately Following Lower Limb Amputation
trial testing Virtual Reality in Phantom Limb Pain in 20 participants. Completed in 5 January 2026.
17 October 2025
Quick facts
| Lead sponsor | University of Manitoba |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 20 |
| Start date | 26 July 2024 |
| Primary completion | 17 October 2025 |
| Estimated completion | 5 January 2026 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Virtual Reality
Conditions studied
- Phantom Limb Pain — all drugs for Phantom Limb Pain →
Sponsor
University of Manitoba
Who can join
Adults 18 to 80, any sex, with Phantom Limb Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to see whether a new virtual reality (VR) program meant to treat phantom limb pain (PLP) is feasible to people immediately following lower limb amputation. This study aims to answer three questions. 1. Is this VR treatment acceptable to people immediately following lower limb amputation? 2. Are the researchers able to recruit participants that represent the population in need of this treatment, and will these participants stay until the end of the study? 3. Do participants who use the VR program more have less severe PLP than participants who use the VR program for fewer sessions? Participants will: * Try the VR program in the hospital, their home, and in physiotherapist clinics daily for about seventeen sessions. * After each session, participants will fill out questionnaires asking about their level of pain, their nausea, and how acceptable they find the program. They will also complete measures asking about how they're feeling and what led to their amputation. * One month following their final VR session, researchers will phone the participants to ask them to rate how severe their PLP is.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Treating Lower Phantom Limb Pain in the Postoperative Acute Care Setting Using Virtual Reality: Protocol for a 4-Phase Development and Feasibility Trial.
El-Gabalawy R, Crooks M, Smith MSD, Hammond E, et al · · 2025 · PMID 40409745 · DOI 10.2196/68008
Verify or expand the search:
- PubMed search for NCT06638918
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Phantom Limb Pain
Currently open trials in the same condition.
- NCT07401966 — Amputations in Childhood and Neuropathic Pain · recruiting
- NCT06719245 — Prevention of PostAmputation Pain With Targeted Muscle Reinnervation · NA · recruiting
- NCT06702904 — Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life · NA · recruiting
- NCT06813937 — Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation · NA · recruiting
- NCT06644807 — Study of Phantom Limb Pain Suppression Using Neuromodulation Methods · NA · recruiting
Other University of Manitoba trials
Trials by the same sponsor.
- NCT07528417 — Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX) · Phase 2 · not yet recruiting
- NCT07366515 — Feasibility of a Multimodal Virtual Reality Intervention to Reduce Preoperative Anxiety in Cancer Surgery Patients · NA · not yet recruiting
- NCT07354386 — Effects of Dried Whole Fruits on Metabolism in Diabetes · NA · enrolling by invitation
- NCT07361315 — Development and Online Evaluation of an Online Course for Parasomnias · NA · recruiting
- NCT07023744 — CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children · Phase 2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06638918 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Manitoba
- Last refreshed: 26 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06638918.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing