NCT06634147: PREDISC

Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults

Recruiting now NA Last updated 18 July 2025

What this trial tests

NA trial testing Exercise in Clinical Deterioration in 296 participants. Currently enrolling.

Timeline

1 February 2025

Primary endpoint
1 November 2026

1 December 2026

Quick facts

Lead sponsor	Fundacion Miguel Servet
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	296
Start date	1 February 2025
Primary completion	1 November 2026
Estimated completion	1 December 2026
Sites	2 locations across Spain

Drugs / interventions tested

• Exercise

Conditions studied

• Clinical Deterioration — all drugs for Clinical Deterioration →

Sponsor

Fundacion Miguel Servet

Who can join

75 and older, any sex, with Clinical Deterioration. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older. Additionally, the study aims to assess the impact of this program on medication use, quality of life, and overall health outcomes. Key questions include whether the program enhances functional and cognitive capacities and which subgroups benefit most, such as frail patients or those with cognitive impairment.

Participants will engage in a structured exercise program that includes strength training, balance exercises, and walking, all designed to improve mobility and reduce fall risk. They will attend supervised sessions several times a week, allowing for individualized attention and adjustments based on their abilities and health status.

Throughout the study, changes in functional capacity will be monitored using standardized assessments that measure mobility, strength, and overall physical functioning. Cognitive assessments will evaluate any changes in cognitive status during the intervention and follow-up periods post-discharge. Participants will provide information on medication usage to analyze whether the exercise program can reduce the need for medications or help manage common polypharmacy issues.

Surveys and interviews will assess participants' quality of life, including physical, emotional, and social well-being, before and after the intervention. Follow-up assessments will track progress and outcomes, ensuring long-term benefits of the exercise program are documented.

The study will include a diverse sample from multiple centers, focusing on individuals aged over 75 who are hospitalized in Geriatrics and Internal Medicine services across participating centers (HUN, CHU-T, ULSBM, and HNSM). Exclusion criteria will ensure safety, excluding those with terminal illnesses or significant contraindications for exercise.

This clinical trial aims to recruit 296 patients, providing valuable insights into the benefits of physical activity for elderly patients during hospitalization and informing future care practices.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Prevention of functional and cognitive impairment through a multicomponent exercise program during and after hospitalization of older adults (PREDISC): Study protocol for a multicenter randomized clinical trial.
   Martínez-Velilla N, Santos Silva R, Rodriguez PA, Xandri JM, et al · · 2025 · PMID 40997056 · DOI 10.1371/journal.pone.0332391