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NCT06634004: BLOSSOM
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
trial testing BOLD MRI in Moyamoya Disease in 100 participants. Enrolling by invitation.
11 September 2029
Quick facts
| Lead sponsor | Vanderbilt University Medical Center |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 11 September 2023 |
| Primary completion | 11 September 2029 |
| Estimated completion | 11 September 2030 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- BOLD MRI
Conditions studied
- Moyamoya Disease — all drugs for Moyamoya Disease →
Sponsor
Vanderbilt University Medical Center
Who can join
Adults 18 to 69, any sex, with Moyamoya Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD). MMD is a condition characterized by narrowing or obstruction of major arteries in the brain and people with MMD have a high risk of stroke. Study participants will be enrolled from Vanderbilt University Medical Center and Johns Hopkins Hospital and will undergo up to two MRI scans where measurements of cerebrovascular reserve are performed using inhaled room air mixed with 5% carbon dioxide. Scans will be performed before and after surgeries to treat MMD, all surgeries are clinically indicated and are not research procedures. To further understand how surgeries impact brain health, we will also perform neurological exams and cognitive testing at approximately the same time as the imaging scans. The overall goal is to incorporate advanced imaging and cognitive assessments to understand how surgeries improve brain health in these patients, and furthermore, to use this information to develop improved screening tools for stroke risk and decisions about surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06634004
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of BOLD MRI
Trials testing the same drug.
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Other recruiting trials for Moyamoya Disease
Currently open trials in the same condition.
- NCT07304947 — Cardiac Index-Guided Intraoperative Hemodynamic Management in Pediatric Moyamoya Surgery · NA · recruiting
- NCT07140731 — The Symani Restore Study · NA · recruiting
- NCT07144930 — Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments · NA · recruiting
- NCT07065409 — Treatment of Moyamoya Disease With iPSC-derived Exosomes · Phase 1 · recruiting
- NCT06832839 — Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease · recruiting
Other Vanderbilt University Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06634004 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
- Last refreshed: 14 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06634004.
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