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NCT06626854
Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System
EARLY_PHASE1 trial testing RF-PNS in Chronic Knee Pain in 5 participants. Not yet recruiting.
10 October 2026
Quick facts
| Lead sponsor | Hypersound Medical Inc |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 5 |
| Start date | 10 June 2026 |
| Primary completion | 10 October 2026 |
| Estimated completion | 10 December 2026 |
Drugs / interventions tested
- RF-PNS
Conditions studied
- Chronic Knee Pain — all drugs for Chronic Knee Pain →
- Chronic Knee Osteoarthritis — all drugs for Chronic Knee Osteoarthritis →
- Post Surgical Neuropathic Pain — all drugs for Post Surgical Neuropathic Pain →
Sponsor
Hypersound Medical Inc
Who can join
Adults 18 to 75, any sex, with Chronic Knee Pain or Chronic Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session. The technician verifies and marks the knee for treatment and wraps an antenna applicator strap around the lower leg near the knee. The device is turned on in test mode to confirm the therapy location, with the subject identifying when they feel a sensation over their pain area. The power threshold for this sensation is recorded. The therapy, which lasts 15 minutes, is delivered at 90% of this threshold to ensure the subject does not feel it. After therapy, post-treatment measurements are taken.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06626854
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Knee Pain
Currently open trials in the same condition.
- NCT07308873 — Individual Differences in Gait and Osteoarthritis Pain · recruiting
- NCT07179016 — Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populati · NA · recruiting
- NCT06514755 — Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain · NA · recruiting
- NCT06709963 — The Effect of Intermittent Theta Burst Stimulation on Brain Characteristics, Pain Intensity, and Cognitive Functions in · NA · recruiting
- NCT05920382 — Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06626854 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hypersound Medical Inc
- Last refreshed: 23 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06626854.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing