Last reviewed · How we verify
NCT06626412
Longitudinal SV2A and MRI in Premanifest HD
NA trial testing Diagnostic Test: 18F-SynVesT-1 PET in Huntington Disease in 35 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 35 |
| Start date | 4 December 2024 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2028 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Diagnostic Test: 18F-SynVesT-1 PET
- Volumetric MRI
Conditions studied
- Huntington Disease — all drugs for Huntington Disease →
Sponsor
Universitaire Ziekenhuizen KU Leuven — full company profile →
Who can join
Adults 20 to 75, any sex, with Huntington Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Huntington's disease clinical trials update: March 2025.
Farag M, Tabrizi SJ, Wild EJ. · · 2025 · cited 7× · PMID 40302443 · DOI 10.1177/18796397251337000 -
Huntington's disease clinical trials update: October 2025.
Farag M, Tabrizi SJ, Wild EJ. · · 2026 · PMID 41295902 · DOI 10.1177/18796397251399751
Verify or expand the search:
- PubMed search for NCT06626412
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Huntington Disease
Currently open trials in the same condition.
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- NCT06774443 — Hinting Task for Huntington's Disease · recruiting
- NCT06546488 — Cognitive Assessment Tools for Huntington's Disease. · recruiting
- NCT07010705 — Digital Measures for Clinical Trial Endpoints in Huntington's Disease · recruiting
Other Universitaire Ziekenhuizen KU Leuven trials
Trials by the same sponsor.
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- NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06626412 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
- Last refreshed: 13 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06626412.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing