Who is sponsoring SnS?

SnS is sponsored by Robin Carhart-Harris, PhD, MA.

What condition does SnS study?

SnS studies Healthy Participants With Lower-than-average Mental Well-being.

What drugs are being tested in SnS?

Interventions: Psilocybin, Context 1, Context 2, Placebo.

Last reviewed 2025-03-27 · How we verify

Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers (SnS)

NCT06626139 PHASE2 RECRUITING

One hundred twenty healthy participants, ages 21 to 70, who experience moderate-to-lower-than-average mental well-being will be evenly randomized into four different study arms, using a 2x2 factorial design. Depending on the study arm, participants will either receive an inactive placebo or up to 25mg psilocybin (oral dose), in one of two set and setting conditions; drug administration contexts that are predicted to modulate drug effects. The purpose of this study is to evaluate any interaction effects between an oral dose of psilocybin and the surrounding context (set and setting).

Details

Lead sponsor	Robin Carhart-Harris, PhD, MA
Phase	PHASE2
Status	RECRUITING
Enrolment	120
Start date	Sun Oct 20 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Nov 30 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Healthy Participants With Lower-than-average Mental Well-being

Interventions

Psilocybin
Context 1
Context 2
Placebo

Countries

United States