NCT06625216: SANI

Severe Asthma Network Italy

Recruiting now Last updated 3 October 2024

What this trial tests

trial in Severe Asthma in 5,000 participants. Currently enrolling.

Timeline

17 February 2017

Primary endpoint
17 February 2027

17 February 2037

Quick facts

Lead sponsor	Società Italiana di Allergologia, Asma e Immunologia Clinica
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	5,000
Start date	17 February 2017
Primary completion	17 February 2027
Estimated completion	17 February 2037
Sites	1 location across Italy

Conditions studied

• Severe Asthma — all drugs for Severe Asthma →

Sponsor

Società Italiana di Allergologia, Asma e Immunologia Clinica

Who can join

13 and older, any sex, with Severe Asthma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this registry is collecting data of severe asthma patients, recruited by specialized centers, in a real life setting, homogeneously placed on a database management system to follow them over the time.

The information recorded will provide:

1. The collection of homogeneous clinical, functional and biologic data of patients with severe asthma in a real life setting.
2. The evaluation of adherence to treatment in real life.
3. The clinical eligibility of patients treated with biologics.
4. The evaluation of patients' clinical response to each treatment.
5. The monitoring of tolerability and safety.
6. The long-term follow up of patients with severe asthma.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI).
   Canonica GW, Blasi F, Paggiaro P, Heffler E, et al · · 2025 · cited 10× · PMID 39829953 · DOI 10.1016/j.waojou.2024.101016
2. Role of body anthropometry in severe asthmatic patients: Evidences from the Severe Asthma Network in Italy (SANI) registry.
   Ridolo E, Ottoni M, Nicoletta F, Locatelli F, et al · · 2025 · cited 2× · PMID 40458738 · DOI 10.1016/j.waojou.2025.101056
3. Digital Innovation in Asthma Management in Italy: Results From the "Confronting Asthma Survey".
   Latorre M, Paggiaro P, Cardini C, Paoletti G, et al · · 2025 · cited 1× · PMID 41105313 · DOI 10.1002/clt2.70109
4. Clinical outcomes and remission trajectories in obese and non-obese patients with severe asthma treated with biologics: a retrospective longitudinal cohort study from the Severe Asthma Network Italy (SANI) registry.
   Di Bona D, Di Gioia G, Heffler E, Parente R, et al · · 2026 · PMID 42164342 · DOI 10.1016/j.lanepe.2026.101695
5. Longitudinal observation of severe asthma comorbidities and oral corticosteroids use from SANI and ISAR registries.
   Guida G, Scelo G, Friston DA, Blasi F, et al · · 2026 · PMID 41783626 · DOI 10.1016/j.waojou.2026.101345
6. Osteoporosis in Severe Asthmatic Patients: Data from the Severe Asthma Network in Italy (SANI) Registry.
   Latorre M, Costanzo G, Ledda AG, Sambugaro G, et al · · 2025 · PMID 41156259 · DOI 10.3390/jcm14207387