Last reviewed · How we verify
NCT06621264: EXACT-CKDPAD
Exercise Activity to Improve Mobility in Patients With CKD and PAD
NA trial testing EXERCISE TRAINING WITH OR WITHOUT MEDICATION in Chronic Kidney Disease Stage 3 and 4 in 124 participants. Currently enrolling.
20 November 2025
Quick facts
| Lead sponsor | University Hospital of Ferrara |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 124 |
| Start date | 1 October 2024 |
| Primary completion | 20 November 2025 |
| Estimated completion | 31 December 2026 |
| Sites | 3 locations across Italy |
Drugs / interventions tested
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION — full drug profile →
- Control (Standard treatment) — full drug profile →
Conditions studied
- Chronic Kidney Disease Stage 3 and 4 — all drugs for Chronic Kidney Disease Stage 3 and 4 →
- Peripheral Artery Disease (PAD) — all drugs for Peripheral Artery Disease (PAD) →
Sponsor
University Hospital of Ferrara
Who can join
Adults 18 to 80, any sex, with Chronic Kidney Disease Stage 3 and 4 or Peripheral Artery Disease (PAD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study. Whose providing informed consent, will be randomly assigned to one of two groups: 1. Exercise program receiving two daily 10-minute interval walking sessions at a slow increasing speed. 2. Control group: receiving usual care including optimal medical therapy and nutritional advice. Patients of both groups will be measured at baseline, after the end of the exercise program (6-month) and at follow up (12-month). Outcome measures will include walking ability by the 6-minute walking test (primary outcome) and lower limbs perfusion, body composition, quality of life, laboratory outcomes and long-term hospitalizations.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical management of peripheral arterial disease in chronic kidney disease-a comprehensive review from the European Renal Association CKD-MBD Working Group.
Huish S, Nawaz S, Bellasi A, Diaz-Tocados JM, et al · · 2025 · cited 4× · PMID 40599821 · DOI 10.1093/ckj/sfaf089 -
Exercise therapy to improve mobility, active behaviour and quality of life of chronic kidney disease patients with peripheral artery disease: study protocol for the EXACT-CKDPAD multicentre randomised controlled trial.
Manfredini F, Panuccio V, Battaglia Y, Storari A, et al · · 2025 · PMID 40672525 · DOI 10.1136/bmjsem-2025-002740
Verify or expand the search:
- PubMed search for NCT06621264
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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Other recruiting trials for Chronic Kidney Disease Stage 3 and 4
Currently open trials in the same condition.
- NCT06933108 — Prediction of Peripheral Neuropathy With Functional Testing · recruiting
Other University Hospital of Ferrara trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06621264 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital of Ferrara
- Last refreshed: 31 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06621264.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing