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NCT06620666: NEUROAGE

NEUROmuscular Training for Enhanced AGE Longevity

Active, enrolled NA Last updated 30 March 2025
What this trial tests

NA trial testing Water-based power resistance training + Dietary supplement I (WPowDSI) in Aging in 390 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline
24 January 2024
Primary endpoint
15 July 2027
15 July 2027

Quick facts

Lead sponsorUniversity of Valencia
PhaseNA
StatusActive, enrolled
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingdouble
Primary purposetreatment
Enrollment390
Start date24 January 2024
Primary completion15 July 2027
Estimated completion15 July 2027
Sites1 location across Spain

Drugs / interventions tested

Conditions studied

Sponsor

University of Valencia

Who can join

60 and older, any sex, with Aging or Physical Activity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In recent years the research group on Prevention and Health in Exercise and Sport (PHES) has carried out numerous studies that have provided current and convincing evidence of the benefits of physical activity and exercise for chronic health, but unfortunately it has also shown that if physical exercise is not properly prescribed it can impair health, as well as accelerating the ageing process. The research proposal presented here aims to reveal some of the forms of physical exercise and resources for its application that may be most beneficial for people's health, thus trying to find reliable evidence that will increase healthy longevity and quality of life in society. Based on the above, and taking into account that the possible beneficial adaptations for health are specific to the applied form of physical exercise and the equipment used during its development, the PHES research group wishes to investigate the most appropriate strategies to ensure an active and positive ageing process. With these relevant findings the researchers can create specific action plans for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy. The general objective of the project is to identify the most advanced methods and material resources with which to guarantee a beneficial process of active and healthy ageing with chronic training, so that with these relevant findings, concrete action plans can be created for prevention and promotion through physical exercise in order to improve both health and quality of life expectancy. The specific objectives are the following: * To validate new, specific, safe, and efficient tools to monitor the intensity of neuromuscular strength training activities in older adults. * To analyze and compare the chronic effects of different cardiovascular and neuromuscular strength training modalities applied with different materials on cellular ageing, body composition, metabolic, and immune profiles, cognitive function, motor function, quality of life and well-being in older adults. * To evaluate the efficacy of the use of dietary supplements to reduce or even stop the chronic adverse effects that different physical activity levels and/or physical exercise programs can have on the oxidative and inflammatory profile, body composition and metabolic profile, muscle and DNA damage, and physical performance in older adults.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Effects of High-Resistance Elastic Band Training and a Curcumin-Based Formulation on Neuro-Oxidative and Functional Health in Sedentary Older Adults.
    Juesas A, Saez-Berlanga A, Gene-Morales J, Jiménez-Martínez P, et al · · 2025 · cited 2× · PMID 40361833 · DOI 10.3390/healthcare13091055
  2. Effects of Accentuated Eccentric and Maximal Strength High-Resistance Training Programs with or Without a Curcumin-Based Formulation Supplement on Body Composition, Blood Pressure, and Metabolic Parameters in Older Adults.
    Juesas A, Saez-Berlanga A, Babiloni-Lopez C, Martin EG, et al · · 2025 · cited 2× · PMID 39997069 · DOI 10.3390/diseases13020062
  3. Dietary Nucleotides Enhance Neurogenesis, Cognitive Capacity, Muscle Function, and Body Composition in Older Adults: A Randomized, Triple-Blind, Controlled Clinical Trial.
    Gene-Morales J, Juesas A, Saez-Berlanga A, Martin EG, et al · · 2025 · cited 1× · PMID 40362739 · DOI 10.3390/nu17091431
  4. Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-con
    Fernandez-Garrido J, Martin EG, Saez-Berlanga A, Gargallo-Bayo P, et al · · 2026 · PMID 41941966 · DOI 10.1016/j.exger.2026.113122
  5. High-Velocity, Accentuated Eccentric, or Maximal Elastic Band Resistance Training? Effects of Resistance Training Modalities on Bone Health, Isokinetic Strength, and Systemic Biomarkers in Sedentary Older Adults: A Comparative Study.
    Saez-Berlanga A, Gene-Morales J, Teixeira AM, Jiménez-Castuera R, et al · · 2025 · PMID 41373346 · DOI 10.3390/healthcare13233129

Verify or expand the search:

Other recruiting trials for Aging

Currently open trials in the same condition.

Other University of Valencia trials

Trials by the same sponsor.

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Data sources for this page

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