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NCT06620432: HISEAL
High Vs. Low Segmental Hysterotomy: Impact on Uterine Wall Defects Post-Cesarean
NA trial testing Low segment hysterotomy in Placenta Accreta Spectrum in 168 participants. Not yet recruiting.
30 June 2026
Quick facts
| Lead sponsor | Fundacion Clinica Valle del Lili |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 168 |
| Start date | 1 December 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 October 2026 |
| Sites | 1 location across Colombia |
Drugs / interventions tested
- Low segment hysterotomy
- High segment hysterotomy
- Crossed hysterorrhaphy
- Non-Crossed hysterorrhaphy
Conditions studied
- Placenta Accreta Spectrum — all drugs for Placenta Accreta Spectrum →
Sponsor
Fundacion Clinica Valle del Lili
Who can join
18 and older, female only, with Placenta Accreta Spectrum. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this clinical trial is to compare the incidence of defects in the uterine wall at the site of the scar (niche) and surgical complications when using high-segment versus low-segment hysterotomy, with both cross-suturing and non-cross-suturing techniques, in pregnant patients undergoing their first cesarean section. Researchers will compare four arms: * Low Segment Hysterotomy + Crossed hysterorrhaphy * High Segment Hysterotomy + Crossed hysterorrhaphy * Low Segment Hysterotomy + Non-Crossed hysterorrhaphy * High Segment Hysterotomy + Non-Crossed hysterorrhaphy Participants will: * Cesarean delivery * Attend a follow up appointment between 6 to 16 weeks post surgery where will be perform a transvaginal sonography.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06620432
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Placenta Accreta Spectrum
Currently open trials in the same condition.
- NCT07025954 — Planned Delivery at 37 Versus 36 Weeks in Pregnancies With Placenta Previaand Accreta · NA · recruiting
- NCT06512181 — Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders · NA · recruiting
- NCT06493968 — Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy · NA · recruiting
- NCT06867874 — Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum · NA · recruiting
- NCT04866888 — Placenta Accreta Spectrum Outcome After Uterine Conservation · NA · recruiting
Other Fundacion Clinica Valle del Lili trials
Trials by the same sponsor.
- NCT06875791 — Safety and Efficacy Trial of TV5M01 for Radiation-Induced Mucositis in Head and Neck Cancer Patients. · Phase 1, PHASE2 · not yet recruiting
- NCT06843265 — Outcomes and Perceptions of the Implementation of the JADA Device in a Stage II Postpartum Hemorrhage Management Protoco · NA · not yet recruiting
- NCT06086080 — Non-operative Treatment in First-time Patellar Dislocation · NA · recruiting
- NCT05922397 — Placenta Accreta Spectrum Topographic Classification · recruiting
- NCT05295641 — American Registry of Ambulatory or Acutely Decompensated Heart Failure · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06620432 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fundacion Clinica Valle del Lili
- Last refreshed: 17 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06620432.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing