Last reviewed · How we verify
NCT06618872: IDV of tau-PET
Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment
NA trial testing PET/CT with RO958 (experimental) in Dementia in 120 participants. Currently enrolling.
30 August 2027
Quick facts
| Lead sponsor | University Hospital, Geneva |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 120 |
| Start date | 3 December 2024 |
| Primary completion | 30 August 2027 |
| Estimated completion | 30 August 2027 |
| Sites | 2 locations across Switzerland |
Drugs / interventions tested
- PET/CT with RO958 (experimental)
Conditions studied
- Dementia — all drugs for Dementia →
- Alzheimer Disease — all drugs for Alzheimer Disease →
Sponsor
University Hospital, Geneva
Who can join
Adults 50 to 85, any sex, with Dementia or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of the study is to investigate the clinical validity of tau-PET with \[18F\]RO948 vs. amyloid-PET in patients with Mild Cognitive Impairment (MCI) or mild dementia
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Revisiting the therapeutic landscape of tauopathies: assessing the current pipeline and clinical trials.
Harris GA, Hirschfeld LR, Gonzalez MI, Pritchard MC, et al · · 2025 · cited 8× · PMID 40462159 · DOI 10.1186/s13195-025-01775-x
Verify or expand the search:
- PubMed search for NCT06618872
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06618872 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Geneva
- Last refreshed: 23 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06618872.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing