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NCT06618716
Individual Differences in Acute Response to Experimental Inflammation: Microcirculatory Changes and Psychological Predictors
NA trial testing endotoxin escherichia coli (E. coli) lipopolysaccharide (LPS) in Inflammation Biomarkers in 25 participants. Completed in 11 March 2025.
31 December 2026
Quick facts
| Lead sponsor | University Hospital, Linkoeping |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 25 |
| Start date | 17 September 2024 |
| Primary completion | 31 December 2026 |
| Estimated completion | 11 March 2025 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- endotoxin escherichia coli (E. coli) lipopolysaccharide (LPS) — full drug profile →
- Placcebo
Conditions studied
- Inflammation Biomarkers — all drugs for Inflammation Biomarkers →
- Inflammation — all drugs for Inflammation →
Sponsor
University Hospital, Linkoeping
Who can join
Adults 18 to 40, any sex, with Inflammation Biomarkers or Inflammation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The physiological and behavioral responses to inflammatory vary greatly between individuals. The knowlegde about what causes these differences is sparse but plausible explanations are variations in sensitivity to peripheral inflammation. The goal of the study is to understand microcirculatory changes in skin and their possible correlation with conventional measurements of sickness and disease in humans. A better understanding of possible psychological predictors of sickness behaviour is also warranted as it may affect the results. The general aim of the study is to assess microcirculatory changes in skin of the face, chest, hands and feet using different optical imaging techniques, and to identify psychological predictors in the acute behavioral response to experimentally induced inflammation. The participants are healthy volunteers in the age of 18-40 years of both sex/genders. The main questions to answer are: 1. How do acute inflammation change microcirculation in the skin as measured by temperature, red blood cell concentration, blood flow and spectral changes correlated with fluids and other proteins. 2. Can a stronger behavioral response to experimental endotoxemia be predicted by psychological factors of the individuals? It is a blinded with-in subject, crossover design where the participants will receive placebo-injection with saline on one study day and LPS-injection the other study day in a randomized order. Participants will on the study days * Fill in psychometric questionnaires * Be measured with bio-optical imaging methods at regular intervalls. * Be monitored with regular medical parameters such as blood pressure, oxygen saturation, puls etc When the volunteers feel recovered and the medical staff are confident of the recovery the volunteers will be discharged.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06618716
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06618716 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Linkoeping
- Last refreshed: 1 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06618716.
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