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NCT06618157
Connectomic Guided DBS for Parkinson's Disease
NA trial testing Cerebellothalamic optimized deep brain stimulation in Parkinson Disease in 20 participants. Enrolling by invitation.
29 December 2026
Quick facts
| Lead sponsor | Duke University |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 16 February 2026 |
| Primary completion | 29 December 2026 |
| Estimated completion | 29 January 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Cerebellothalamic optimized deep brain stimulation
- Pallidothalamic optimized deep brain stimulation
- No deep brain stimulation
- Usual care deep brain stimulation
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
- Tremor — all drugs for Tremor →
- Dyskinesias — all drugs for Dyskinesias →
Sponsor
Duke University
Who can join
18 and older, any sex, with Parkinson Disease or Tremor. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this research is to use advanced connectomic imaging models to identify disease-relevant axonal pathway targets for better tremor control in Parkinson's disease patients while avoiding undesirable side effects, with the goal of increasing precision and facilitating the choice of optimal DBS parameters for certain disease phenotypes. The investigators hypothesize that patient centered subthalamic nucleus deep brain stimulation of cerebellothalamic axonal pathways and pallidothalamic tract activation can provide better tremor control while avoiding worsening dyskinesias in patients with Parkinson's disease with significant tremor.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06618157
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06618157 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Duke University
- Last refreshed: 20 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06618157.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing