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NCT06617494: TMD-CPM
Endogenous Pain Inhibition Deficiency in Chronic TMD Pain
trial testing Pain modulation testing in Chronic Temporomandibular Disorders (TMD) in 40 participants. Currently enrolling.
15 September 2026
Quick facts
| Lead sponsor | University of Minnesota |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 16 September 2024 |
| Primary completion | 15 September 2026 |
| Estimated completion | 15 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Pain modulation testing
Conditions studied
- Chronic Temporomandibular Disorders (TMD) — all drugs for Chronic Temporomandibular Disorders (TMD) →
Sponsor
University of Minnesota
Who can join
Adults 18 to 74, any sex, with Chronic Temporomandibular Disorders (TMD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Temporomandibular disorders (TMDs) involve a range of conditions with varied causes, affecting a large portion of the U.S. population and posing challenges for diagnosis and management, especially in chronic cases. Despite advances in understanding TMD pathophysiology, the role of central sensitization, particularly deficient endogenous pain inhibition, remains unclear. The conditioned pain modulation (CPM) test, used to assess pain inhibition in chronic TMD pain, has produced inconsistent results due to varying testing parameters. The proposed cross-sectional study will investigate the efficiency of endogenous pain inhibition in individuals with chronic TMD pain compared to controls by applying noxious and non-noxious stimuli to facial and non-facial sites. The findings aim to clarify the impact of weaker pain inhibition over the face, how the conditioning stimulus' painfulness affects inhibition and the relationship between pain inhibition and fluctuations in TMD pain intensity.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06617494
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06617494 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Minnesota
- Last refreshed: 19 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06617494.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing