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NCT06611137
SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx
Phase 2 trial testing SBRT+Toripalimab Plus Docetaxel and Cisplatin in Laryngeal Cancer in 35 participants. Currently enrolling.
11 September 2025
Quick facts
| Lead sponsor | Sun Yat-sen University |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 35 |
| Start date | 11 September 2024 |
| Primary completion | 11 September 2025 |
| Estimated completion | 11 September 2027 |
| Sites | 1 location across China |
Drugs / interventions tested
- SBRT+Toripalimab Plus Docetaxel and Cisplatin
Conditions studied
- Laryngeal Cancer — all drugs for Laryngeal Cancer →
- Hypopharynx Cancer — all drugs for Hypopharynx Cancer →
Sponsor
Sun Yat-sen University
Who can join
Adults 18 to 70, any sex, with Laryngeal Cancer or Hypopharynx Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This trial aims to evaluate the safety and efficiency of SBRT followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Systemic therapy for laryngeal carcinoma.
Fuereder T, Kocher F, Vermorken JB. · · 2025 · cited 4× · PMID 40104492 · DOI 10.3389/fonc.2025.1541385
Verify or expand the search:
- PubMed search for NCT06611137
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Laryngeal Cancer
Currently open trials in the same condition.
- NCT07209189 — Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca · Phase 2 · recruiting
- NCT06761937 — Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients · Phase 1 · recruiting
- NCT06077643 — Workshops and Exchange Groups for Laryngectomized Patients · recruiting
- NCT05894070 — The Voice as a Tool to Detect Recurrence of Laryngeal and Hypopharyngeal Cancer · recruiting
- NCT05375266 — Immune Biomarker Study for Head and Neck Cancer · recruiting
Other Sun Yat-sen University trials
Trials by the same sponsor.
- NCT07255612 — Bone Marrow Protection, Safety, Efficacy of Trilaciclib and Eribulin in Locally Advanced or Metastatic TNBC(Triple-negat · Phase 2 · not yet recruiting
- NCT07371897 — Toripalimab ± Chemo as Neoadjuvant Therapy in LA-HNSCC: A Phase III Trial · Phase 3 · not yet recruiting
- NCT07489703 — SHR-A1811 + AK112 in HER2-Altered Advanced/Metastatic NSCLC · Phase 2 · not yet recruiting
- NCT07528209 — Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer · Phase 3 · recruiting
- NCT07522281 — Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06611137 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sun Yat-sen University
- Last refreshed: 26 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06611137.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing