Last reviewed · How we verify
NCT06608316
Intermittent Theta-burst Stimulation for Mild Cognitive Impairment
NA trial testing Intermittent Theta Burst Stimulation in Mild Cognitive Impairment (MCI) in 66 participants. Currently enrolling.
31 October 2026
Quick facts
| Lead sponsor | The Hong Kong Polytechnic University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 66 |
| Start date | 1 November 2024 |
| Primary completion | 31 October 2026 |
| Estimated completion | 31 October 2027 |
| Sites | 2 locations across Hong Kong |
Drugs / interventions tested
- Intermittent Theta Burst Stimulation
Conditions studied
- Mild Cognitive Impairment (MCI) — all drugs for Mild Cognitive Impairment (MCI) →
Sponsor
The Hong Kong Polytechnic University
Who can join
65 and older, any sex, with Mild Cognitive Impairment (MCI). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objectives of this study are to: 1. Evaluating the Impact of iTBS on Cognitive and Physical Functions: The investigators will investigate the efficacy of intermittent theta burst stimulation (iTBS) in patients with mild cognitive impairment (MCI), focusing on its effects on dual-task walking abilities, balance abilities, and cognitive function. 2. Comparing Clinical Efficacy Based on Stimulation Sites: The investigators will compare the clinical efficacy of iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) versus bilateral DLPFC stimulation. This comparison aims to directly examine potential differences in therapeutic outcomes based on the site of stimulation. 3. Investigating Neurophysiological Mechanisms: The investigators plan to elucidate the neurophysiological mechanisms underlying the improvements in cognitive functions and dual-task walking abilities in MCI patients facilitated by iTBS. This will be achieved using fNIRS neuroimaging of brain activity.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06608316
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intermittent Theta Burst Stimulation
Trials testing the same drug.
- NCT07188376 — Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation · NA · recruiting
- NCT05591677 — D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT) · Phase 2 · active not recruiting
- NCT05322239 — Resting State Changes Following Theta Burst Stimulation · NA · recruiting
- NCT07181226 — High-Frequency vs. Theta-Burst TMS for Depression · NA · completed
- NCT05119660 — Modulation of Frontoparietal Dynamics Underlying Adolescent Working Memory Deficits · NA · unknown
Other recruiting trials for Mild Cognitive Impairment (MCI)
Currently open trials in the same condition.
- NCT07516119 — Predicting Pre-dementia · recruiting
- NCT07526740 — Brain Stimulation and Cognitive Training for MCI · NA · recruiting
- NCT07101380 — Feasibility Study of 'SuperBrain BOOM' for Mild Cognitive Impairment Patients · NA · recruiting
- NCT07420426 — Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Perso · NA · recruiting
- NCT07286448 — Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment · NA · recruiting
Other The Hong Kong Polytechnic University trials
Trials by the same sponsor.
- NCT07505732 — Information-providing Chatbot · NA · not yet recruiting
- NCT07391449 — Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis · NA · not yet recruiting
- NCT07450248 — The Use of Telephone-based ACT for Quitting Alcohol in the Young Population With Hazardous or Harmful Alcohol Use. · NA · not yet recruiting
- NCT07273682 — Nurse-led Transitional Care to Improve Symptom Management in Childhood Cancer Survivors · NA · not yet recruiting
- NCT07531082 — Effects of a Salutogenic Strength-based Social Robot-assisted Intervention on the Depressive Symptoms and Sense of Coher · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06608316 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Hong Kong Polytechnic University
- Last refreshed: 13 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06608316.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing