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NCT06606652
Caffeine, Resistance Exercise and EMG
NA trial testing Caffeine in Caffeine in 12 participants. Completed in 30 April 2024.
30 April 2024
Quick facts
| Lead sponsor | University of Alcala |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | other |
| Enrollment | 12 |
| Start date | 1 September 2023 |
| Primary completion | 30 April 2024 |
| Estimated completion | 30 April 2024 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Caffeine (caffeine) — full drug profile →
- Placebo
Conditions studied
- Caffeine — all drugs for Caffeine →
Sponsor
University of Alcala
Who can join
Adults 18 to 35, any sex, with Caffeine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: Several studies have evaluated and confirmed the ergogenic effects of acute caffeine intake on sports performance. However, some studies suggest that this effect predominantly occurs in large muscle groups, potentially due to increased skeletal muscle electrical activity. Objectives: This study aims to evaluate the acute effects of caffeine intake on strength, power, muscle endurance, and muscle electrical activity in young adults. It will also analyze the influence of circadian rhythms (morning vs. afternoon) on exercise performance (bench press vs. squat). Methods: Twelve healthy, physically active participants will be recruited for the study. Using a triple-blind, crossover, randomized, and controlled design, participants will ingest either caffeine (3 mg/kg body mass) or a placebo (maltodextrin, 3 mg/kg) 60 minutes before the trial. Muscular strength, power, and endurance performance will then be assessed through 1RM tests, and at 25%, 50%, 75%, and 90% of 1RM, along with muscle endurance tests at 65% of 1RM, for both squat and bench press exercises. EMG will be used to measure skeletal muscle electrical activity during the tests. The experimental sessions will be conducted in the morning (8:00 am to 10:00 am) and the afternoon (4:30 pm to 6:30 pm).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Acute caffeine intake improves muscular strength, power, and endurance performance, reversing the time-of-day effect regardless of muscle activation level in resistance-trained males: a randomized controlled trial.
Montalvo-Alonso JJ, Del Val-Manzano M, Cerezo-Telléz E, Ferragut C, et al · · 2025 · cited 5× · PMID 40478455 · DOI 10.1007/s00421-025-05820-3
Verify or expand the search:
- PubMed search for NCT06606652
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT07479875 — Caffeine Supplementation and Strength Endurance in Brazilian Jiu-jitsu Athletes · NA · completed
- NCT07466732 — Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males · EARLY_PHASE1 · enrolling by invitation
- NCT07458594 — Combined Caffeine and Rhodiola Rosea on Aerial Duel Performance in Soccer · NA · completed
Other recruiting trials for Caffeine
Currently open trials in the same condition.
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- NCT07404254 — Effects of Variations in Caffeinated Beverages on Well-being · NA · recruiting
- NCT06763172 — Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI · Phase 4 · recruiting
- NCT05325502 — Does Caffeine Facilitate Human Reward Learning Behaviors? · NA · active not recruiting
- NCT05454332 — The Caffeine Therapy in the Fetal to Neonatal Transition · Phase 4 · recruiting
Other University of Alcala trials
Trials by the same sponsor.
- NCT06599164 — Evaluation of Vastus Medialis Muscle Inhibition in Indoor Soccer Players With and Without ACL Injury · not yet recruiting
- NCT06587412 — Treatment of Lateral Epicondylalgia With Shock Waves · NA · recruiting
- NCT07333443 — Caffeine and Sport Climbing Performance · NA · completed
- NCT07015008 — Sleep and Maximal Fat Oxidation · NA · completed
- NCT06723821 — Noninvasive Neuromodulation in the Management of Post-COVID Musculoskeletal Pain · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06606652 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Alcala
- Last refreshed: 23 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06606652.
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