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NCT06595758

This Study Investigates the Impact of Single Nucleotide Polymorphisms in Genes Involved in the Pharmacokinetics and Toxicity of Doxorubicin (DOX) in Egyptian Female Patients with Breast Cancer. It Also Aims to Explore the Association of Pretreatment Neutrophil to Lymphocyte Ratio to PCR

Completed Last updated 19 September 2024
What this trial tests

trial in Breast Cancer in 100 participants. Completed in 1 November 2023.

Timeline
1 October 2021
Primary endpoint
1 November 2022
1 November 2023

Quick facts

Lead sponsorMenoufia University
StatusCompleted
Study typeOBSERVATIONAL
Enrollment100
Start date1 October 2021
Primary completion1 November 2022
Estimated completion1 November 2023
Sites1 location across Egypt

Conditions studied

Sponsor

Menoufia University

Who can join

Adults 18 to 75, female only, with Breast Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in doxorubicin transport and metabolism on its pharmacokinetics and toxicity in Egyptian breast cancer patients. It also aims to explore the association of pretreatment neutrophil to lymphocyte ratio (NLR) with pathological complete response (pCR).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Is the Neutrophil-to-Lymphocyte Ratio a Predictive Factor of Pathological Complete Response in Egyptian Breast Cancer Patients Treated with Neoadjuvant Chemotherapy?
    Ebaid NF, Abdelkawy KS, Said ASA, Al-Ahmad MM, et al · · 2025 · PMID 40005444 · DOI 10.3390/medicina61020327

Verify or expand the search:

Other recruiting trials for Breast Cancer

Currently open trials in the same condition.

Other Menoufia University trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06595758.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing