Last reviewed · How we verify
NCT06588452: MAPS-LLM
Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models
trial testing RECTIFIER - a generative artificial intelligence screening tool in Comparing Manual and AI Patient Screening in Heart Failure in 4,500 participants. Currently enrolling.
13 September 2024
Quick facts
| Lead sponsor | Brigham and Women's Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 4,500 |
| Start date | 4 March 2024 |
| Primary completion | 13 September 2024 |
| Estimated completion | 13 September 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- RECTIFIER - a generative artificial intelligence screening tool
- Manual clinical trial screening by study staff
Conditions studied
- Comparing Manual and AI Patient Screening in Heart Failure — all drugs for Comparing Manual and AI Patient Screening in Heart Failure →
Sponsor
Brigham and Women's Hospital
Who can join
Adults 18 to 90, any sex, with Comparing Manual and AI Patient Screening in Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients from the Mass General Brigham Electronic Data Warehouse (EDW), who will then be randomized into either the manual review arm or the AI-assisted review arm.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models-A Randomized Clinical Trial.
Unlu O, Varugheese M, Shin J, Subramaniam SM, et al · · 2025 · cited 15× · PMID 39960745 · DOI 10.1001/jama.2024.28047
Verify or expand the search:
- PubMed search for NCT06588452
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06588452 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06588452.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing