Last reviewed · How we verify
NCT06587347: TREND-2
Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke
Phase 2, PHASE3 trial testing Tirofiban Hydrochloride in Acute Stroke in 302 participants. Not yet recruiting.
30 June 2026
Quick facts
| Lead sponsor | Capital Medical University |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 302 |
| Start date | 20 November 2024 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Tirofiban Hydrochloride — full drug profile →
- Standard medical treatment (SMT) — full drug profile →
Conditions studied
- Acute Stroke — all drugs for Acute Stroke →
- Ischemic Stroke, Acute — all drugs for Ischemic Stroke, Acute →
- Cerebral Infarction — all drugs for Cerebral Infarction →
Sponsor
Capital Medical University
Who can join
18 and older, any sex, with Acute Stroke or Ischemic Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A prospective, multicenter, randomized, controlled, open-label, blinded endpoint trial to evaluate the safety and efficacy of intravenous administration of tirofiban for preventing early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06587347
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tirofiban Hydrochloride
Trials testing the same drug.
- NCT05604638 — Early Administration of Tirofiban in Patients Treated With Tenecteplase for Acute Ischemic Stroke · Phase 3 · recruiting
- NCT04818944 — Clinical Trial to Evaluate the Safety of Continuous IV Tirofiban in Acute Ischemic Stroke · Phase 1, PHASE2 · withdrawn
- NCT04491695 — Tirofiban for the Prevention of Neurological Deterioration in Acute Ischemic Stroke · Phase 2, PHASE3 · unknown
- NCT03406832 — Prevention of Coronary Slow Flow or No-Reflow During EPCI in Patients With Acute STEMI · NA · unknown
- NCT03406819 — Prevention of Coronary Slow Flow or No-Reflow During PPCI in Patients With Acute STEMI · NA · unknown
Other recruiting trials for Acute Stroke
Currently open trials in the same condition.
- NCT07491952 — Continuous Dual Aspiration Technique With Zoom System for Stroke · recruiting
- NCT07295366 — Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Cont · Phase 4 · recruiting
- NCT07355881 — mSOAR and Early Mortality in Acute Stroke · recruiting
- NCT07301372 — Evaluation Study of Early Administration of Evolocumab After Thrombolysis in Patients With Atherosclerotic Acute Ischemi · Phase 4 · recruiting
- NCT07167550 — The Study of Efficacy and Safety of Dimephosphon® in Acute Ischemic Stroke · Phase 3 · recruiting
Other Capital Medical University trials
Trials by the same sponsor.
- NCT07379437 — Haematococcus Pluvialis Astaxanthin for Brain Aging · NA · not yet recruiting
- NCT07531394 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic St · Phase 3 · not yet recruiting
- NCT07509645 — Efficacy and Safety of Interleukin-6 Receptor Inhibitor Combined With Endovascular Treatment in Patients With Acute Post · Phase 3 · recruiting
- NCT07513233 — Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL) · Phase 1 · not yet recruiting
- NCT07495358 — Development and Usability Evaluation of a Knowledge Graph-Based Symptom Management System for Patients With Breast Cance · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06587347 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Capital Medical University
- Last refreshed: 29 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06587347.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing