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Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid Ultrasound
Current understanding suggests that the majority of cardiovascular events are driven by vulnerable plaques. Nonetheless, the impact of PCSK9 inhibitors on the stability of carotid plaques remains insufficiently elucidated, with a notable scarcity of relevant clinical studies. This investigation seeks to address this gap through a real-world study conducted among patients with arterial sclerosis in Asia. The primary aim is to evaluate the effects of small interfering RNA (inclisiran) on carotid plaque characteristics as assessed by ultrasound, thereby contributing valuable data to inform clinical practice.
Details
| Lead sponsor | First Affiliated Hospital of Xinjiang Medical University |
|---|---|
| Phase | PHASE4 |
| Status | NOT_YET_RECRUITING |
| Enrolment | 40 |
| Start date | Fri Sep 20 2024 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Sep 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Carotid Plaque
- Hyperlipidemia
- Echocardiography
Interventions
- Inclisiran