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NCT06581679
Adenomyosis and Pregnancy: Levonorgestrel vs. GnRH for Blastocyst Transfer
NA trial testing Triptorelin in Adenomyosis in 184 participants. Completed in 1 July 2024.
10 April 2024
Quick facts
| Lead sponsor | Zagazig University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 184 |
| Start date | 15 December 2023 |
| Primary completion | 10 April 2024 |
| Estimated completion | 1 July 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Triptorelin (triptorelin) — full drug profile →
- levonorgestrel-releasing intrauterine system — full drug profile →
- frozen embryo transfer — full drug profile →
Conditions studied
- Adenomyosis — all drugs for Adenomyosis →
Sponsor
Zagazig University
Who can join
Adults 30 to 65, female only, with Adenomyosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Adenomyosis is a condition where endometrial tissue grows into the uterine muscle, causing symptoms like pelvic pain, heavy bleeding, and infertility. This abnormal growth can lead to a variety of reproductive issues, including a higher risk of miscarriage and early pregnancy loss. While there are treatments available for adenomyosis, they are often limited due to the lack of precise diagnostic criteria. One common approach is the use of gonadotropin-releasing hormone agonist (GnRHa), which can improve pregnancy rates in infertile women with adenomyosis. However, it's important to note that GnRHa may not restore pregnancy rates to baseline levels. Another potential treatment option is the levonorgestrel-releasing intrauterine system (LNG-IUS). This device releases a hormone called levonorgestrel into the uterus, which can help control the symptoms of endometriosis and adenomyosis. Studies have shown that the endometrial concentration of levonorgestrel from the LNG-IUS is significantly higher than in other tissues like the myometrium, fallopian tubes, and fat tissue.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06581679
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Adenomyosis
Currently open trials in the same condition.
- NCT07455721 — Central Sensitization in Women With Adenomyosis: Prevalence, Risk Factors, and Therapeutic Failure · active not recruiting
- NCT07486622 — Transvaginal Electromechanical Fragmentation and Removal of Large Uterus in a Sealed Bag: The First Group of Clinical St · active not recruiting
- NCT06572852 — Next-Generation Endometriosis Diagnostics Through Comprehensive Multi-Dimensional Analysis · recruiting
- NCT06364592 — Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis · NA · recruiting
- NCT06604091 — Cohort Profile：The Shandong Adenomyosis Cohort of Population Undergoing Reproductive Technology (SAart) · active not recruiting
Other Zagazig University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06581679 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zagazig University
- Last refreshed: 3 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06581679.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing